The Oxidative Stress in Knee Osteoarthritis Patients. An Attempt of Evaluation of Possible Compensatory Effects Occurring in the Disease Development
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Biochemical Procedures
2.3. Statistics
3. Results
4. Discussion
Limitations
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Parameters | Control n = 21 | OA Patients n = 67 | p |
---|---|---|---|
Clinical Parameters | |||
WBC (109/L) | 6.57 ± 1.24 | 7.09 ± 1.80 | 0.21738 (t) |
RBC (1012/L) | 4.55 ± 0.64 | 4.47 ± 0.51 | 0.52731 (t) |
HGB (g/dL) | 14.0 (12.4–15.2) | 14.0 (12.2–14.5) | 0.22108 (U) |
HCT (%) | 39.7 ± 4.9 | 39.2 ± 4.1 | 0.60931 (t) |
MCV (fL) | 87.1 ± 3.2 | 88.0 ± 4.9 | 0.41259 (t) |
MCH (pg) | 29.7 ± 1.4 | 29.7 ± 2.0 | 0.97653 (t) |
MCHC (g/dL) | 34.2 ± 1.2 | 33.7 ± 1.1 | 0.10841 (t) |
RDW-CV (%) | 13.1 (12.6–13.7) | 13.6 * (12.9–14.2) | 0.03887 (U) |
PLT (109/L) | 225 (195–254) | 233 (204–261) | 0.36004 (U) |
PDW (%) | 11.4 (10.8–13.9) | 11.7 (11.0–13.0) | 0.95706 (U) |
MPV (fL) | 10.0 (9.8–11.1) | 10.3 (9.8–11.0) | 0.70990 (U) |
P-LCR (%) | 28.9 ± 7.6 | 28.7 ± 6.8 | 0.91403 (t) |
PCT (%) | 0.25 (0.20–0.26) | 0.25 (0.21–0.28) | 0.51190 (U) |
Antioxidant Parameters | |||
TAS (mmol/L) | 4.70 ± 0.60 | 4.39 ± 0.53 * | 0.02626 (t) |
GPx (U/L) | 675 ± 149 | 518 ± 176 *** | 0.00042 (t) |
SOD(U/mL) | 127 ± 42 | 109 ± 32 * | 0.04224 (t) |
CAT (U/mL) | 23.3(14.0–37.0) | 22,1 (11.6–34.9) | 0.82567 (U) |
Parameter | C-Male n = 11 | C-Female n = 10 | OA-Male n = 18 | OA-Female n = 49 |
---|---|---|---|---|
WBC (109/L) (HSD) | 6.30 ± 0.84 a | 6.86 ± 1.56 a | 7.32 ± 1.63 a | 7.01 ± 1.87 a |
RBC (1012/L) (HSD) | 5.06 ± 0.23 a | 3.99 ± 0.45 b | 4.79 ± 0.47 a | 4.35 ± 0.48 b |
HGB (g/dL) | 15.2 | 12.3 | 14.9 | 13.0 |
(KW) | (14.9–15.5) a | (11.9–12.5) b | (13.9–15.3) a | (11.8–13.7) b |
HCT (%) (HSD) | 43.4 ± 1.7 a | 35.8 ± 4.2 b | 42.3 ± 3.3 a | 38.1 ± 3.7 b |
MCV (fL) (HSD) | 85.6 ± 1.7 a | 88.7 ± 3.6 a | 88.7 ± 4.7 a | 87.8 ± 5.0 a |
MCH (pg) | 29.7 | 29.1 | 30.5 | 29.5 |
(KW) | (29.5–30.1) a | (28.7–39.0) a | (28.9–31.7) a | (28.1–31.0) a |
MCHC (g/dL) | 35.0 | 33.5 | 34.3 | 33.6 |
(KW) | (34.6–35.2) a | (32.7–34.1) b | (34.0–35.1) a | (33.0–34.1) b |
RDW-CV (%) | 12.6 | 13.7 | 13.5 | 13.7 |
(KW) | (12.4–13.1) a | (13.1–14.2) a,b | (12.9–14.2) a,b | (12.9–14.1) b |
PLT (109/L] | 246 | 205 | 210 | 239 |
(KW) | (195–258] a | (194–230] a | (180–233) a | (221–264) a |
PDW (%] | 11.4 | 11.7 | 11.7 | 11.7 |
(KW) | (10.6–15.0) a | (10.9–13.9) a | (10.9–12.8) a | (11.1–13.0) a |
MPV (fL] | 10.0 | 10.0 | 10.1 | 10.3 |
(KW) | (9.5–11.4] a | (9.9–11.1) a | (9.8–10.9) a | (9.8–11.0) a |
P-LCR (%] | 25.5 | 26.4 | 26.2 | 28.0 |
(KW) | (21.6–35.8] a | (24.3–34.8] a | (23.4–31.7) a | (24.9–33.2) a |
PCT (%] | 0.25 | 0.24 | 0.21 | 0.26 |
(KW) | (0.18–0.26) a,b | (0.20–0.27) a,b | (0.19–0.24) a | (0.23–0.28) b |
Parameter | C-Male n = 11 | OA-Male n = 18 | C-Female n = 10 | OA-Female n = 49 |
---|---|---|---|---|
TAS (mmol/L) (HSD) | 4.41 ± 0.52 a | 4.61 ± 0.54 a,c | 5.02 ± 0.54 b,c | 4.31 ± 0.51 a |
GPx (U/L) (HSD) | 715 ± 105 a | 482 ± 185 b,c | 630 ± 181 a,c | 532 ± 173 a,c |
SOD (U/mL) (HSD) | 127 ± 39 a | 115 ± 22 a | 127 ± 48 a | 107 ± 35 a |
CAT (U/mL) | 14.0 | 26.9 | 38.5 | 20.2 |
(KW) | (7.0–18.6) a | (23.3–46.5) b,d | (27.9–46.6) c,d | (11.6–31.6) a,b |
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Paździor, M.; Kiełczykowska, M.; Kurzepa, J.; Luchowska-Kocot, D.; Kocot, J.; Musik, I. The Oxidative Stress in Knee Osteoarthritis Patients. An Attempt of Evaluation of Possible Compensatory Effects Occurring in the Disease Development. Medicina 2019, 55, 150. https://doi.org/10.3390/medicina55050150
Paździor M, Kiełczykowska M, Kurzepa J, Luchowska-Kocot D, Kocot J, Musik I. The Oxidative Stress in Knee Osteoarthritis Patients. An Attempt of Evaluation of Possible Compensatory Effects Occurring in the Disease Development. Medicina. 2019; 55(5):150. https://doi.org/10.3390/medicina55050150
Chicago/Turabian StylePaździor, Marek, Małgorzata Kiełczykowska, Jacek Kurzepa, Dorota Luchowska-Kocot, Joanna Kocot, and Irena Musik. 2019. "The Oxidative Stress in Knee Osteoarthritis Patients. An Attempt of Evaluation of Possible Compensatory Effects Occurring in the Disease Development" Medicina 55, no. 5: 150. https://doi.org/10.3390/medicina55050150