Early Diagnosis and Prognostic Value of Acute Kidney Injury in Critically Ill Patients
Abstract
:1. Introduction
2. Materials and Methods
weight (kg) on hospital admission
3. Statistical Analysis
4. Results
5. Discussion
6. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Diagnosis | Group 1 without AKI (n = 75, 70.1%) | Group 2 with AKI (n = 32, 29.9%) |
---|---|---|
Sepsis | 18 (16.8) | 9 (8.4) |
Burns | 9 (8.4) | 4 (3.7) |
Seizures | 1 (0.9) | 2 (1.9) |
Intoxication | 3 (2.8) | 1 (0.9) |
Arrhythmia | 1 (0.9) | 0 (0) |
Complicated IVRA | 2 (1.9) | 0 (0) |
Trauma | 23 (21.5) | 11 (10.3) |
Blood loss | 7 (6.5) | 1 (0.9) |
Hypovolemia | 2 (1.9) | 2 (1.9) |
Meningitis | 2 (1.9) | 2 (1.9) |
Other | 7 (6.5) | 0 (0) |
Characteristic | Group 1 without AKI (n = 75, 70.1%) | Group 2 with AKI (n = 32, 29.9%) | p |
---|---|---|---|
PIM2, score | |||
Mean ± SD | 8.79 ± 18.51 | 12.46 ± 19.10 | 0.035 |
Median (25–75%) | 2.8 (1.2–6.4) | 5.7 (2.4–13.6) | |
Duration of disease until hospitalization, days | |||
Mean ± SD | 0.89 ± 1.86 | 0.53 ± 1.08 | 0.609 |
(range) | (0–11.0) | (0–5.0) | |
PICU length of stay, days | |||
Mean ± SD | 6.36 ± 7.66 | 11.47 ± 16.06 | 0.053 |
Median (25–75%) | 4.0 (2.0–7.0) | 6.0 (3.0–11.75) | |
Bed days | |||
Mean ± SD | 24.29 ± 23.51 | 48.84 ± 58.84 | 0.028 |
Median (25–75%) | 17.0 (10.0–29.0) | 23.0 (16.0–68.25) |
Variable. | OR | 95% CI | p |
---|---|---|---|
Age of <20 months | 7.39 | 2.69–20.28 | 0.001 |
PIM2 score > 2.5 | 2.92 | 1.16–7.32 | 0.001 |
PICU length of stay >three days | 2.42 | 0.99–59.27 | 0.05 |
Bed days > 55 | 5.23 | 1.70–16.02 | 0.002 |
Length of mechanical ventilation > 5 days | 4.90 | 1.63–14.82 | 0.003 |
Multiple organ dysfunction (3 and more organ systems) | 3.98 | 1.54–10.32 | 0.003 |
uNGAL/uCr of >8.22 ng/mg on day 1 | 3.76 | 1.58–8.94 | 0.002 |
uNGAL of >4.3 ng/mL on day 3 | 3.60 | 1.51–8.59 | 0.003 |
Variable | Group 1 (Patients without AKI) (n = 75) | Group 2 (Patients with AKI) (n = 32) | p |
---|---|---|---|
uNGAL on day 1 | |||
Mean ± SD, ng/mL | 5.98 ± 8.74 | 15.9 ± 27.03 | 0.04 |
Median (25–75%) | 2.5 (0.53–6.78) | 2.99 (1.44–10.45) | |
uNGAL on day 3 | |||
Mean ± SD, ng/mL | 4.80 ± 6.23 | 10.07 ± 12.08 | 0.018 |
Median (25–75%) | 1.84 (0.42–6.88) | 7.56 (0.79–12.65) | |
uNGAL/uCr on day 1 | |||
Mean ± SD, ng/mg | 20.35 ± 46.13 | 94.05 ± 200.38 | 0.007 |
Median (25–75%) | 4.67 (1.1–14.11) | 12.10 (2.47–90.27) | |
uNGAL/uCr on day 3 | |||
Mean ± SD, ng/mg | 14.08 ± 25.25 | 42.06 ± 78.56 | 0.015 |
Median (25–75%) | 3.94 (1.79–14.66) | 12.48 (2.62–14.48) | |
uIL-18 on day 1 | |||
Mean ± SD, ng/L | 62.33 ± 15.51 | 62.49 ± 10.15 | 0.959 a |
uIL-18 on day 3 | |||
Mean ± SD, ng/L | 61.46 ± 17.22 | 60.75 ± 12.95 | 0.834 a |
uIL-18/uCr on day 1 | |||
Mean ± SD, ng/mg | 0.20 ± 0.21 | 0.37 ± 0.43 | 0.062 |
Median (25–75%) | 0.13 (0.06–0.21) | 0.20(0.07–0.63) | |
uIL-18/uCr on day 3 | |||
Mean ± SD, ng/mg | 0.24 ± 0.25 | 0.25 ± 0.27 | 0.509 |
Median (25–75%) | 0.13 (0.06–0.35) | 0.15 (0.08–0.34) |
Variable | OR | 95% CI | p |
---|---|---|---|
FO > 15% on day 3 | 6.76 | 1.24–36.93 | 0.024 |
FO > 10% on day 5 | 6.63 | 1.59–27.62 | 0.004 |
Variable | OR | 95% CI |
---|---|---|
FO > 15% on day 3 | 5.77 | 0.99–33.82 |
Any of diagnoses | 6.82 | 1.13–41.05 |
Multiple organ dysfunction of ≥3 organ systems | 20.01 | 3.26–122.97 |
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Dobilienė, D.; Masalskienė, J.; Rudaitis, Š.; Vitkauskienė, A.; Pečiulytė, J.; Kėvalas, R. Early Diagnosis and Prognostic Value of Acute Kidney Injury in Critically Ill Patients. Medicina 2019, 55, 506. https://doi.org/10.3390/medicina55080506
Dobilienė D, Masalskienė J, Rudaitis Š, Vitkauskienė A, Pečiulytė J, Kėvalas R. Early Diagnosis and Prognostic Value of Acute Kidney Injury in Critically Ill Patients. Medicina. 2019; 55(8):506. https://doi.org/10.3390/medicina55080506
Chicago/Turabian StyleDobilienė, Diana, Jūratė Masalskienė, Šarūnas Rudaitis, Astra Vitkauskienė, Jurgita Pečiulytė, and Rimantas Kėvalas. 2019. "Early Diagnosis and Prognostic Value of Acute Kidney Injury in Critically Ill Patients" Medicina 55, no. 8: 506. https://doi.org/10.3390/medicina55080506