Cadmium Induces Acute Liver Injury by Inhibiting Nrf2 and the Role of NF-κB, NLRP3, and MAPKs Signaling Pathway
Abstract
:1. Introduction
2. Materials and Methods
2.1. Reagents and Antibodies
2.2. Animals and Treatments
2.3. Analysis of Serum ALT/AST Activities
2.4. ELISA Assay
2.5. Liver Histological Analysis
2.6. Western Blot Analysis
2.7. Statistical Analysis
3. Results
3.1. Cadmium Increases the Activities of ALT/AST
3.2. Cadmium Induces Pro-Inflammatory Cytokines Expression in Serum
3.3. Cadmium Induces Histopathological Changes
3.4. Cadmium Treatment Results in Nrf2 Inhibition in Liver
3.5. Cadmium Treatment Results in NF-κB p65, NLRP3, and MAPKs Activation in Liver
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Liu, C.; Zhu, Y.; Lu, Z.; Guo, W.; Tumen, B.; He, Y.; Chen, C.; Hu, S.; Xu, K.; Wang, Y.; et al. Cadmium Induces Acute Liver Injury by Inhibiting Nrf2 and the Role of NF-κB, NLRP3, and MAPKs Signaling Pathway. Int. J. Environ. Res. Public Health 2020, 17, 138. https://doi.org/10.3390/ijerph17010138
Liu C, Zhu Y, Lu Z, Guo W, Tumen B, He Y, Chen C, Hu S, Xu K, Wang Y, et al. Cadmium Induces Acute Liver Injury by Inhibiting Nrf2 and the Role of NF-κB, NLRP3, and MAPKs Signaling Pathway. International Journal of Environmental Research and Public Health. 2020; 17(1):138. https://doi.org/10.3390/ijerph17010138
Chicago/Turabian StyleLiu, Chang, Yaohui Zhu, Zhenxiang Lu, Weina Guo, Bayaer Tumen, Yalan He, Chao Chen, Shanshan Hu, Kangzhi Xu, Yan Wang, and et al. 2020. "Cadmium Induces Acute Liver Injury by Inhibiting Nrf2 and the Role of NF-κB, NLRP3, and MAPKs Signaling Pathway" International Journal of Environmental Research and Public Health 17, no. 1: 138. https://doi.org/10.3390/ijerph17010138