Pharmacoeconomics Aspects of Antiepileptic Drugs in Pediatric Patients with Epilepsy
Abstract
:1. Introduction
2. Methods
2.1. Study Group
2.2. Treatment Efficacy Assessment
2.3. Calculation of Pharmacotherapy Costs
2.4. Statistical Analysis
3. Results
3.1. Study Group
3.2. Treatment Efficacy
3.3. Incremental Cost-Effectiveness Ratio
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Age; average ± SD | 8.33 ± 4.37 |
Duration of epilepsy, years (average ± SD) | 4.11 ± 1.22 |
Type of seizures; n (%) | |
generalized | 43 (64.17) |
focal | 24 (35.83) |
Type of AEDs; n (%) | |
OLDER: | 29 (43.28) |
Valproate | (43.37%) |
Phenytoin | (26.31%) |
Carbamazepine | (19.80%) |
Clobazam | (10.52%) |
NEWER: | 38 (56.71) |
Levetiracetam | (32.32%) |
Vigabatrin | (17.68%) |
Oxcarbazepine | (14.27%) |
Topiramate | (12.42%) |
Lacosamide | (2.63%) |
Lamotrigine | (20.68%) |
Older AEDs (n = 29) | Newer AEDs (n = 38) | p-Value Older AEDs vs. Newer AEDs at Baseline/Follow-Up | ||||||
---|---|---|---|---|---|---|---|---|
Baseline | Follow-Up | p-Value | Baseline | Follow-Up | p-Value | Baseline | Follow-Up | |
Average seizure frequency per month (mean ± SD) | 9.93 (3.26) | 7.76 (2.98) | 0.0106 | 7.98 (3.88) | 4.72 (1.23) | <0.0001 | 0.0328 | <0.00001 |
QOLCE-55 (mean ± SD) | 33.51 (19.49) | 39.12 (16.01) | 0.1747 | 34.62 (16.12) | 41.45 (12.09) | 0.0738 | 0.8045 | 0.5155 |
PSQI (mean ± SD) | 4.62 (2.72) | 3.12 (1.09) | 0.0091 | 5.66 (3.74) | 3.17 (1.15) | 0.0003 | 0.2110 | 0.8575 |
LAEP (mean ± SD) | 29.72 (8.30) | 27.53 (8.18) | 0.3160 | 31.41 (9.50) | 25.91 (8.63) | 0.0101 | 0.4492 | 0.4391 |
Older AEDs | Newer AEDs | Difference | ICER | |
---|---|---|---|---|
The total average cost of pharmacotherapy in EUR (±SD) | 42.98 (±9.12) | 83.12 (±12.03) | 40.14 (±8.90) | |
Change of average seizure frequency per month for 6 months | 2.17 | 3.26 | 1.09 | 36.82 # |
Improvement in QOLCE-55 mean scores at the end of the study as compared with enrollment | 5.61 | 6.83 | 1.22 | 32.90 # |
Improvement in PSQI mean scores at the end of the study as compared with enrollment | 1.5 | 2.49 | 0.99 | 40.54 # |
Improvement in LAEP mean scores at the end of the study as compared with enrollment | 2.19 | 5.5 | 3.31 | 12.12 # |
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Kopciuch, D.; Fliciński, J.; Steinborn, B.; Winczewska-Wiktor, A.; Paczkowska, A.; Zaprutko, T.; Ratajczak, P.; Nowakowska, E.; Kus, K. Pharmacoeconomics Aspects of Antiepileptic Drugs in Pediatric Patients with Epilepsy. Int. J. Environ. Res. Public Health 2022, 19, 7517. https://doi.org/10.3390/ijerph19127517
Kopciuch D, Fliciński J, Steinborn B, Winczewska-Wiktor A, Paczkowska A, Zaprutko T, Ratajczak P, Nowakowska E, Kus K. Pharmacoeconomics Aspects of Antiepileptic Drugs in Pediatric Patients with Epilepsy. International Journal of Environmental Research and Public Health. 2022; 19(12):7517. https://doi.org/10.3390/ijerph19127517
Chicago/Turabian StyleKopciuch, Dorota, Jędrzej Fliciński, Barbara Steinborn, Anna Winczewska-Wiktor, Anna Paczkowska, Tomasz Zaprutko, Piotr Ratajczak, Elżbieta Nowakowska, and Krzysztof Kus. 2022. "Pharmacoeconomics Aspects of Antiepileptic Drugs in Pediatric Patients with Epilepsy" International Journal of Environmental Research and Public Health 19, no. 12: 7517. https://doi.org/10.3390/ijerph19127517