UVA Photoirradiation of Halogenated-Polycyclic Aromatic Hydrocarbons Leading to Induction of Lipid Peroxidation
Abstract
:Introduction
Materials and Methods
Materials
Synthesis of Halo-PAHs
Light Source
Peroxidation of Methyl Linoleate Initiated by Photoirradiation of Halogenated Pahs and their Parent Pahs with UVA Light
Results and Discussion
Photoirradiation of Representative Halo-PAHs
Comparison of Level of Lipid Peroxidation Formation
Anthracene Series
Phenenthrene Series
Benz[a]anthracene Series
Benzo[a]pyrene Series
Conclusion
- Upon photoirration with UVA light, all the halo-PAHs used in this study induced lipid peroxidation, but with different induction potencies.
- The levels of lipid peroxidation by each halo-PAHs and PAHs were dose (light) dependent.
- In general, the addition of a halogen atom to the parent PAH resulted in lipid peroxidation either increase, decrease or no effect on the capability of induction of lipid peroxidation.
- There was no correlation between the level of lipid peroxidation and the tumorigenic potency of the compounds studied.
- Halo-PAHs are environmental contaminants and, as shown in our study, can induce lipid peroxidation, these compounds may pose adverse health effect in humans.
Compound | 0 J/cm2 | 7 J/cm2 | 21 J/cm2 |
---|---|---|---|
Methyl linoleate (ML) | 145 | 212 ± 34 | 267 ± 47 |
2-Br-Naph | 137 | 402 ± 49 | 1135 ± 93 |
Anthracene (A) | 138 | 1350 ± 66 | 2459 ± 197 |
1-Cl-A | 122 | 1976 ± 100 | 3759 ± 218 |
9,10-DiBr-A | 137 | 2260 ± 150 | 5144 ± 330 |
Phenanthrene (Ph) | 144 | 321 ± 13 | 803 ± 37 |
9-Cl-Ph | 138 | 645 ± 22 | 1301 ± 100 |
9-Br-Ph | 134 | 537 ± 27 | 721 ± 58 |
Benz[a]anthracene (BA) | 141 | 2719 ± 133 | 3917 ± 403 |
7-Cl-BA | 119 | 2540 ± 179 | 3640 ± 225 |
7-Br-BA | 137 | 2494 ± 301 | 5309 ± 638 |
5MBA | 142 | 1582 ± 58 | 1885 ± 236 |
7-Br-5MBA | 115 | 2296 ± 112 | 3769 ± 216 |
Benzo[a]pyrene (BaP) | 100 | 2467 ± 217 | 5819 ± 425 |
6-Cl-BaP | 153 | 2404 ± 29 | 4840 ± 137 |
6-Br-BaP | 135 | 2639 ± 224 | 5201 ± 291 |
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Herreno-Sáenz, D.; Xia, Q.; Chiu, L.-T.; Fu, P.P. UVA Photoirradiation of Halogenated-Polycyclic Aromatic Hydrocarbons Leading to Induction of Lipid Peroxidation. Int. J. Environ. Res. Public Health 2006, 3, 191-195. https://doi.org/10.3390/ijerph2006030022
Herreno-Sáenz D, Xia Q, Chiu L-T, Fu PP. UVA Photoirradiation of Halogenated-Polycyclic Aromatic Hydrocarbons Leading to Induction of Lipid Peroxidation. International Journal of Environmental Research and Public Health. 2006; 3(2):191-195. https://doi.org/10.3390/ijerph2006030022
Chicago/Turabian StyleHerreno-Sáenz, Diógenes, Qingsu Xia, Li-Ting Chiu, and Peter P. Fu. 2006. "UVA Photoirradiation of Halogenated-Polycyclic Aromatic Hydrocarbons Leading to Induction of Lipid Peroxidation" International Journal of Environmental Research and Public Health 3, no. 2: 191-195. https://doi.org/10.3390/ijerph2006030022