Overexpression of AKR1B10 Predicts Poor Prognosis in Gastric Cancer Patients Undergoing Surgical Resection

Round 1

Reviewer 1 Report

The study tried to prove that AKR1B10 overexpression can be an independent prognostic factor for worse survival in GC patients who underwent gastrectomy with D2 lymph node dissection.

The paper is clear in logic and rich in content, but there are still some limitations：

1.Bioinformatics analysis needs to be added to verify the conclusions of this paper.

2.The construction and validation of prediction model are also required in this paper.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

This quite interesting manuscript has tried to demonstrate the prognostic significance of AKR1B10. The most beautiful section is the “discussion” part, which has brilliantly demonstrated the limitation of the study and put the several question marks. The introduction, method and result section is quite okay. Although there are couple of issues, which need to address:

1.     What is the unique finding of the manuscript comparing with similar previous study of Ahmed et al., 2019?

2.     Is there any data of serum AKR1B10 level of these patients?

3.     Dose the AKR1B10 expression correlate with lymph metastasis only?

4.     Despite significant outcome, why did you not highlight the association of AKR1B10 expression on adjuvant chemotherapy in result section? Can adjuvant chemotherapy induce AKR1B10 overexpression?

5.     Do only signet ring carcinoma samples correlate with AKR1B10 expression?

 

I would recommend including more interesting findings to improve the quality of the manuscript. Thanks again for your wonderful effort to make a nice manuscript.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

The authors have well completed the revision.

Reviewer 2 Report

Thanks to the authors for their wonderful effort to make the better manuscript.