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Volume 13
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10.3390/ma13183911
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Article

Exploratory Full-Field Mechanical Analysis across the Osteochondral Tissue—Biomaterial Interface in an Ovine Model

by
Jeffrey N. Clark
1,2,
Agathe Heyraud
2,
Saman Tavana
1,
Talal Al-Jabri
3,
Francesca Tallia
2,
Brett Clark
4,
Gordon W. Blunn
5,
Justin P. Cobb
3,
Ulrich Hansen
1,
Julian R. Jones
2 and
Jonathan R. T. Jeffers
1,*
1
Department of Mechanical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
2
Department of Materials, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
3
Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK
4
Imaging and Analysis Centre, Natural History Museum London, London SW7 5BD, UK
5
School of Pharmacy and Biomedical Science, University of Portsmouth, Portsmouth PO1 2DT, UK
*
Author to whom correspondence should be addressed.
Materials 2020, 13(18), 3911; https://doi.org/10.3390/ma13183911
Submission received: 31 July 2020 / Revised: 31 August 2020 / Accepted: 1 September 2020 / Published: 4 September 2020
(This article belongs to the Special Issue Digital Image/Volume Correlation of Biological Tissues and Biomaterials)
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Abstract

Osteochondral injuries are increasingly prevalent, yet success in articular cartilage regeneration remains elusive, necessitating the development of new surgical interventions and novel medical devices. As part of device development, animal models are an important milestone in illustrating functionality of novel implants. Inspection of the tissue-biomaterial system is vital to understand and predict load-sharing capacity, fixation mechanics and micromotion, none of which are directly captured by traditional post-mortem techniques. This study aims to characterize the localised mechanics of an ex vivo ovine osteochondral tissue–biomaterial system extracted following six weeks in vivo testing, utilising laboratory micro-computed tomography, in situ loading and digital volume correlation. Herein, the full-field displacement and strain distributions were visualised across the interface of the system components, including newly formed tissue. The results from this exploratory study suggest that implant micromotion in respect to the surrounding tissue could be visualised in 3D across multiple loading steps. The methodology provides a non-destructive means to assess device performance holistically, informing device design to improve osteochondral regeneration strategies.
Keywords: biomaterials; cartilage regeneration; digital volume correlation; tissue-biomaterial interface; tissue regeneration; micro-CT; in situ mechanics; X-ray computed tomography; phase-contrast imaging biomaterials; cartilage regeneration; digital volume correlation; tissue-biomaterial interface; tissue regeneration; micro-CT; in situ mechanics; X-ray computed tomography; phase-contrast imaging
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MDPI and ACS Style

Clark, J.N.; Heyraud, A.; Tavana, S.; Al-Jabri, T.; Tallia, F.; Clark, B.; Blunn, G.W.; Cobb, J.P.; Hansen, U.; Jones, J.R.; et al. Exploratory Full-Field Mechanical Analysis across the Osteochondral Tissue—Biomaterial Interface in an Ovine Model. Materials 2020, 13, 3911. https://doi.org/10.3390/ma13183911

AMA Style

Clark JN, Heyraud A, Tavana S, Al-Jabri T, Tallia F, Clark B, Blunn GW, Cobb JP, Hansen U, Jones JR, et al. Exploratory Full-Field Mechanical Analysis across the Osteochondral Tissue—Biomaterial Interface in an Ovine Model. Materials. 2020; 13(18):3911. https://doi.org/10.3390/ma13183911

Chicago/Turabian Style

Clark, Jeffrey N., Agathe Heyraud, Saman Tavana, Talal Al-Jabri, Francesca Tallia, Brett Clark, Gordon W. Blunn, Justin P. Cobb, Ulrich Hansen, Julian R. Jones, and et al. 2020. "Exploratory Full-Field Mechanical Analysis across the Osteochondral Tissue—Biomaterial Interface in an Ovine Model" Materials 13, no. 18: 3911. https://doi.org/10.3390/ma13183911

APA Style

Clark, J. N., Heyraud, A., Tavana, S., Al-Jabri, T., Tallia, F., Clark, B., Blunn, G. W., Cobb, J. P., Hansen, U., Jones, J. R., & Jeffers, J. R. T. (2020). Exploratory Full-Field Mechanical Analysis across the Osteochondral Tissue—Biomaterial Interface in an Ovine Model. Materials, 13(18), 3911. https://doi.org/10.3390/ma13183911

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