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Pharmaceutics
Volume 12
Issue 8
10.3390/pharmaceutics12080739
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Article

Therapeutic Efficacy of Curcumin Enhanced by Microscale Discoidal Polymeric Particles in a Murine Asthma Model

by
Jun Young Park
1,
Ga Eul Chu
2,
Sanghyo Park
3,
Chaewon Park
3,
Susmita Aryal
3,
Won Jun Kang
1,
Won Gil Cho
2,* and
Jaehong Key
3,*
1
Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea
2
Department of Anatomy, Yonsei University Wonju College of Medicine, 20 Ilsan-ro, Wonju 26426, Korea
3
Department of Biomedical Engineering, Yonsei University, Gangwon-do, Wonju 26493, Korea
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2020, 12(8), 739; https://doi.org/10.3390/pharmaceutics12080739
Submission received: 12 June 2020 / Revised: 1 July 2020 / Accepted: 3 August 2020 / Published: 6 August 2020
(This article belongs to the Special Issue Depot Delivery Systems: Recent Advances on Materials, Technologies, and Beyond)
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Abstract

Curcumin is considered a potential anti-asthmatic agent owing to its anti-inflammatory properties. The objective of the present study was to prepare curcumin-containing poly(lactic-co-glycolic acid)-based microscale discoidal polymeric particles (Cur-PLGA-DPPs) and evaluate their anti-asthmatic properties using a murine asthma model. Cur-PLGA-DPPs were prepared using a top-down fabrication method. The prepared Cur-PLGA-DPPs had a mean particle size of 2.5 ± 0.4 μm and a zeta potential value of −34.6 ± 4.8 mV. Ex vivo biodistribution results showed that the Cur-PLGA-DPPs mainly accumulated in the lungs and liver after intravenous injection. Treatment with Cur-PLGA-DPPs effectively suppressed the infiltration of inflammatory cells in bronchoalveolar lavage fluid, and reduced bronchial wall thickening and goblet-cell hyperplasia compared to those in the phosphate-buffered-saline-treated control group. No significant changes in hematology and blood biochemistry parameters were observed after treatment with Cur-PLGA-DPPs. At equal curcumin concentrations, treatment with Cur-PLGA-DPPs exhibited better therapeutic efficacy than treatment with free curcumin. Our results suggest that the microscale Cur-PLGA-DPPs can be potentially used as a lung-targeted asthma therapy.
Keywords: discoidal polymeric particle; asthma; drug delivery system; microparticle; curcumin discoidal polymeric particle; asthma; drug delivery system; microparticle; curcumin
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MDPI and ACS Style

Park, J.Y.; Chu, G.E.; Park, S.; Park, C.; Aryal, S.; Kang, W.J.; Cho, W.G.; Key, J. Therapeutic Efficacy of Curcumin Enhanced by Microscale Discoidal Polymeric Particles in a Murine Asthma Model. Pharmaceutics 2020, 12, 739. https://doi.org/10.3390/pharmaceutics12080739

AMA Style

Park JY, Chu GE, Park S, Park C, Aryal S, Kang WJ, Cho WG, Key J. Therapeutic Efficacy of Curcumin Enhanced by Microscale Discoidal Polymeric Particles in a Murine Asthma Model. Pharmaceutics. 2020; 12(8):739. https://doi.org/10.3390/pharmaceutics12080739

Chicago/Turabian Style

Park, Jun Young, Ga Eul Chu, Sanghyo Park, Chaewon Park, Susmita Aryal, Won Jun Kang, Won Gil Cho, and Jaehong Key. 2020. "Therapeutic Efficacy of Curcumin Enhanced by Microscale Discoidal Polymeric Particles in a Murine Asthma Model" Pharmaceutics 12, no. 8: 739. https://doi.org/10.3390/pharmaceutics12080739

APA Style

Park, J. Y., Chu, G. E., Park, S., Park, C., Aryal, S., Kang, W. J., Cho, W. G., & Key, J. (2020). Therapeutic Efficacy of Curcumin Enhanced by Microscale Discoidal Polymeric Particles in a Murine Asthma Model. Pharmaceutics, 12(8), 739. https://doi.org/10.3390/pharmaceutics12080739

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