Designing of Co0.5Ni0.5GaxFe2−xO4 (0.0 ≤ x ≤ 1.0) Microspheres via Hydrothermal Approach and Their Selective Inhibition on the Growth of Cancerous and Fungal Cells
Abstract
:1. Introduction
2. Materials and Methods
2.1. Synthesis and Characterizations of MCs
2.2. Anti-Cancer Activity
2.2.1. Cell Culture and Testing of Nanoparticles Using MTT Method
2.2.2. DAPI Staining for DNA Analysis
2.3. Anti-Candidal Activity
2.3.1. Preparation of Inoculum and Nanomaterial
2.3.2. Study of CFU and Morphogenesis of C. albicans
3. Results and Discussion
3.1. Microstructural Analysis of Co0.5Ni0.5GaxFe2−xO4 (0.0 ≤ x ≤ 1.0) MCs
3.2. Biological Activities
3.2.1. Impact of Co0.5Ni0.5GaxFe2−xO4 (0.0 ≤ x ≤ 1.0) MCs on Cancer Cell Viability
3.2.2. Disintegration of Cancer Cell DNA
3.2.3. Anti-Fungal Activity
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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x | IC50 (HCT-116) Cells (µg/mL) | IC50 (HeLa) Cells (µg/mL) | IC50 (HEK-293) Cells |
---|---|---|---|
0.0 | 25 ± 2 | 35 ± 4 | No inhibition |
0.2 | 46 ± 3 | 56 ± 4 | No inhibition |
0.4 | 42 ± 4 | 48 ± 5 | No inhibition |
0.6 | 29 ± 2 | 50 ± 5 | No inhibition |
0.8 | 50 ± 5 | 49 ± 4 | No inhibition |
1.0 | 59 ± 5 | 60 ± 5 | No inhibition |
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Rehman, S.; Almessiere, M.A.; Al-Jameel, S.S.; Ali, U.; Slimani, Y.; Tashkandi, N.; Al-Saleh, N.S.; Manikandan, A.; Khan, F.A.; Al-Suhaimi, E.A.; et al. Designing of Co0.5Ni0.5GaxFe2−xO4 (0.0 ≤ x ≤ 1.0) Microspheres via Hydrothermal Approach and Their Selective Inhibition on the Growth of Cancerous and Fungal Cells. Pharmaceutics 2021, 13, 962. https://doi.org/10.3390/pharmaceutics13070962
Rehman S, Almessiere MA, Al-Jameel SS, Ali U, Slimani Y, Tashkandi N, Al-Saleh NS, Manikandan A, Khan FA, Al-Suhaimi EA, et al. Designing of Co0.5Ni0.5GaxFe2−xO4 (0.0 ≤ x ≤ 1.0) Microspheres via Hydrothermal Approach and Their Selective Inhibition on the Growth of Cancerous and Fungal Cells. Pharmaceutics. 2021; 13(7):962. https://doi.org/10.3390/pharmaceutics13070962
Chicago/Turabian StyleRehman, Suriya, Munirah A. Almessiere, Suhailah S. Al-Jameel, Uzma Ali, Yassine Slimani, Nedaa Tashkandi, Najat S. Al-Saleh, Ayyar Manikandan, Firdos Alam Khan, Ebtesam A. Al-Suhaimi, and et al. 2021. "Designing of Co0.5Ni0.5GaxFe2−xO4 (0.0 ≤ x ≤ 1.0) Microspheres via Hydrothermal Approach and Their Selective Inhibition on the Growth of Cancerous and Fungal Cells" Pharmaceutics 13, no. 7: 962. https://doi.org/10.3390/pharmaceutics13070962