The History and Applications of Phage Therapy in Pseudomonas aeruginosa
, Sara Sá 1,5, Carla Guedes 1,4, Carla Oliveira 1,2,6, Cláudio Lima 1,7, Marco Oliveira 1,8, João Mendes 1,2, Gonçalo Novais 1,2, Pilar Baylina 1,2,* and Ruben Fernandes 1,2,*Round 1
Reviewer 1 Report
Good paper, in the "frame" of the Journal and could be of interest for the readers. Also, Pseudomonas aeruginosa is one of the bacteria determines serious infections due to resistance to many antibiotics today.
Hard points:
The authors present in an "itinerant" way stages/of phage therapy development to solve the problem of resistant, presenting the phage therapy as an effective therapeutic mean in resistant Pseudomonas aeruginosa strains.
The "problem of bacterial resistance" is well presented also the phages classification and infection process description.
It was a nice manuscript to read! The review is well done work focusing specifically to a topic but deep.
Weak point:
Being a Review (and an important one) the number of cited studies is, for sure, improvable (and there are easy findable in the main-stream) - I suggest to enlarge the list of authors.
Author Response
Thank you very much for your kind comment. Here we present the response to ALL comments of the reviewer.
In the manuscript, the authors highlighted in yellow the alterations suggested by the reviewer 1 and in pink the alterations suggested by reviewer 2. We also highlighted in green minor correction that the authors found in the revision.
The answer to reviewers will written in blue by the authors.
ANSWER TO REVIEWER 1:
“Good paper, in the "frame" of the Journal and could be of interest for the readers. Also, Pseudomonas aeruginosa is one of the bacteria determines serious infections due to resistance to many antibiotics today.”
Authors(A): Thank you very much for the time spent in contributing for the improvement of our work.
Hard points:
The authors present in an "itinerant" way stages/of phage therapy development to solve the problem of resistant, presenting the phage therapy as an effective therapeutic mean in resistant Pseudomonas aeruginosa strains.
The "problem of bacterial resistance" is well presented also the phages classification and infection process description.
It was a nice manuscript to read! The review is well done work focusing specifically to a topic but deep.
A: Thank you very much your kind comments.
Weak point:
Being a Review (and an important one) the number of cited studies is, for sure, improvable (and there are easy findable in the main-stream) - I suggest to enlarge the list of authors.
A: Thank you very much your kind comments. The authors reinforced the list of authors (bibliographic references), and contributed to this by introducing Table 3, 4 and 5, describe some in vivo and in vitro and clinical studies carried out in recent years to test the effectiveness of phage therapy against Pseudomonas aeruginosa , as well as the number of effective authors of the article, actions that aimed to respond to the reviewer's suggestion and enrich the article even further.
Reviewer 2 Report
Dear Ms Kesley Chen
MDPI Microbiology Research Editorial Office
I am sending my review comments to the manuscript Microbiology ResearchNumber- 1425363 entitled: The history and applications of phage therapy in Pseudomonas aeruginosa
Comments to the Author
The manuscript prepared by Carina Silva and co- workers describe the problem of bacterial resistance in P. aeruginosa and the significant increase in antibiotic resistant strains and the scarcity of new antibiotics requires, in the immediate future, the discovery of new effective therapies, such as phage therapy.
Conclusion is too short.
conclusion in the work – should be improuved.
After careful reading of this paper I am of the opinion that the work is suitable to Microbiology Research
With Regards
Dr Elżbieta Szacon
Author Response
Thank you very much for your kind comment. Here we present the response to ALL comments of the reviewer.
In the manuscript, the authors highlighted in yellow the alterations suggested by the reviewer 1 and in pink the alterations suggested by reviewer 2. We also highlighted in green minor correction that the authors found in the revision.
The answer to reviewers will written in blue by the authors.
ANSWER TO REVIEWER 2:
The manuscript prepared by Carina Silva and co- workers describe the problem of bacterial resistance in P. aeruginosa and the significant increase in antibiotic resistant strains and the scarcity of new antibiotics requires, in the immediate future, the discovery of new effective therapies, such as phage therapy.”
A: Thank you very much your kind comments.
Weak point:
Conclusion is too short.
conclusion in the work – should be improuved.
A: Thank you very much your kind comments. We made some changes to the conclusion.
