Meningioma–Brain Crosstalk: A Scoping Review
Abstract
:Simple Summary
Abstract
1. Introduction
- (1)
- Attraction and activation of glial cells from the parenchyma to the tumour site;
- (2)
- Reciprocal exchange of substances and cell–cell interactions between glial cells and tumour cells that impact on meningioma growth and behaviour.
2. Methods
(meningioma[MeSH Terms]) AND (astrocytes[MeSH Terms]) OR (meningioma[MeSH Terms]) AND (microglia[MeSH Terms]) OR (meningioma[MeSH Terms]) AND (receptors, chemokine[MeSH Terms]) OR (meningioma[MeSH Terms]) AND (“chemokines”[MeSH Terms]) OR (meningioma[MeSH Terms]) AND (cytokines[MeSH Terms])
3. Results
3.1. Microglia/Macrophage Infiltration in Meningiomas
3.2. Classical (M1) or Alternative (M2) Microglia/Macrophage Activation in Meningiomas
3.3. Glial Response at the Tumour–Brain Interface
3.4. Cytokine Expression in Meningiomas
3.5. Microenvironmental Impact on Meningioma Growth and Behaviour
3.6. Sources and Targets of Cytokines in Meningiomas
4. Discussion
4.1. Meningioma–Brain Crosstalk: Current Research Knowledge Base
4.2. Research Gaps and Future Research Recommendations
5. Limitations of This Review
6. Conclusions
Author Contributions
Funding
Conflicts of Interest
Supervision
Appendix A. PRISMA Flow Diagram
References
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Cytokine | n. Positive Meningiomas/Total | Cytokine Receptors | +/n.a. |
---|---|---|---|
Type 1 Cytokine Family | |||
IL-2 | 0/5 [38], 0/9 [39], 0/11 [40] | IL-2R | n.a. |
IL-3 | 11/11 [40] | IL-3R | n.a. |
IL-4 | 0/11 [40], 0/5 [38], 0/9 [39] | IL-4R | + [41,42] |
IL-5 | 0/11 [40], 1/5 [38] | IL-5R | n.a. |
IL-6 | 11/11 [40], 1/5 [38], 10/10 [43], 9/9 [39], 0/2 [44], 10/10 [45] | IL-6R | + [43] |
IL-7 | 0/11 [40] | IL-7R | n.a. |
G-CSF | 28/30 [46] | G-CSFR | + [46] |
GM-CSF | 1/5 [38], 27/30 [46] | GM-CSFR | + [46] |
Type 2 Cytokine Family | |||
IFN-γ | 11/11 [40] | IFN-γR | n.a. |
IL-10 | 1/5 [38] | IL-10R | n.a. |
OSM | 2/2 [44], 10/10 [43] | OSM-R | + [43] |
LIF | 2/2 [44], 10/10 [43] | LIF-R | + [43] |
TNF Cytokine family | |||
TNF-α | 3/5 [38], 0/11 [40] | TNFR1 | n.a. |
TNF-β | 6/11 [40] | TNFR1 | n.a. |
IL-1 Family | |||
IL-1α | 0/11 [40], 5/5 [38] | IL-1R | n.a. |
IL-1β | 5/11 [40], 3/5 [38], 9/9 [39] | IL-1R | n.a. |
Other Cytokines | |||
TGF-α | 22/26 [47] | EGFR | + [47,48,49] |
TGF-β1 | 8/11 [40], 3/5 [38], 3/6 [50] | TGF-βRI-III | + [51] |
TGF-β2 | 9/11 [40], 5/5 [38], 6/6 [50] | - | - |
TGF-β3 | 11/11 [40], 5/5 [38], 6/6 [50] | - | - |
HGF/SF | 5/14 [52] | MET | + [52,53] |
Chemokines | |||
IL-8 | 11/11 [40], 14/35 [54] | CXCR1/2 | + [54] |
CCL2/MCP-1 | 16/16 [18] | CCR2 | n.a. |
CXCL1/2/3 | 27/27 [54] | CXCR1/2 | + [54] |
CXCL9 | 10/36 [54] | CXCR3 | + [54] |
CXCL10 | 15/36 [54] | CXCR3 | + [54] |
CXCL11 | 22/22 [55] | CXCR3 | + [54] |
CXCL12/SDF-1 | 22/22 [55], 6/6 [56], 29/55 [54] | CXCR4/CXCR7 | + [25,55,56,57] |
CXCL13 | 1/35 [54] | CXCR5 | + [54] |
CXCL16 | 27/27 [58], 28/28 [59] | CXCR6/tmCXCL16 | (+)/+ [58,59] |
CX3CL1 | 27/27 [58] | CX3CR1 | + [58] |
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Borch, J.d.S.; Haslund-Vinding, J.; Vilhardt, F.; Maier, A.D.; Mathiesen, T. Meningioma–Brain Crosstalk: A Scoping Review. Cancers 2021, 13, 4267. https://doi.org/10.3390/cancers13174267
Borch JdS, Haslund-Vinding J, Vilhardt F, Maier AD, Mathiesen T. Meningioma–Brain Crosstalk: A Scoping Review. Cancers. 2021; 13(17):4267. https://doi.org/10.3390/cancers13174267
Chicago/Turabian StyleBorch, Josefine de Stricker, Jeppe Haslund-Vinding, Frederik Vilhardt, Andrea Daniela Maier, and Tiit Mathiesen. 2021. "Meningioma–Brain Crosstalk: A Scoping Review" Cancers 13, no. 17: 4267. https://doi.org/10.3390/cancers13174267