Using Electronic Medical Records to Identify Potentially Eligible Study Subjects for Lung Cancer Screening with Biomarkers
Abstract
:Simple Summary
Abstract
1. Introduction
2. Issues and Approaches to Current Lung Cancer Screening Programmes
3. Can Records Be Used to Aid in Identifying Eligible Subjects for Screening?
3.1. What Codes Are Associated with LC and Appear in EMRs?
3.2. Use of Free Text to Identify Eligible Participants?
4. What Are the Challenges in Using EMR Data to Detect and Identify High-Risk Populations?
5. Future Research
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Appendix A
Read Code | Read Term | Condition |
---|---|---|
B220100 | Malignant neoplasm of mucosa of trachea | Primary Malignancy-Lung |
B220.00 | Malignant neoplasm of trachea | Primary Malignancy-Lung |
B220z00 | Malignant neoplasm of trachea NOS | Primary Malignancy-Lung |
B221000 | Malignant neoplasm of carina of bronchus | Primary Malignancy-Lung |
B221100 | Malignant neoplasm of hilus of lung | Primary Malignancy-Lung |
B221.00 | Malignant neoplasm of main bronchus | Primary Malignancy-Lung |
B221z00 | Malignant neoplasm of main bronchus NOS | Primary Malignancy-Lung |
B222000 | Malignant neoplasm of upper lobe bronchus | Primary Malignancy-Lung |
B222100 | Malignant neoplasm of upper lobe of lung | Primary Malignancy-Lung |
B222.00 | Malignant neoplasm of upper lobe, bronchus or lung | Primary Malignancy-Lung |
B222.11 | Pancoast’s syndrome | Primary Malignancy-Lung |
B222z00 | Malignant neoplasm of upper lobe, bronchus or lung NOS | Primary Malignancy-Lung |
B223000 | Malignant neoplasm of middle lobe bronchus | Primary Malignancy-Lung |
B223100 | Malignant neoplasm of middle lobe of lung | Primary Malignancy-Lung |
B223.00 | Malignant neoplasm of middle lobe, bronchus or lung | Primary Malignancy-Lung |
B223z00 | Malignant neoplasm of middle lobe, bronchus or lung NOS | Primary Malignancy-Lung |
B224000 | Malignant neoplasm of lower lobe bronchus | Primary Malignancy-Lung |
B224100 | Malignant neoplasm of lower lobe of lung | Primary Malignancy-Lung |
B224.00 | Malignant neoplasm of lower lobe, bronchus or lung | Primary Malignancy-Lung |
B224z00 | Malignant neoplasm of lower lobe, bronchus or lung NOS | Primary Malignancy-Lung |
B225.00 | Malignant neoplasm of overlapping lesion of bronchus and lung | Primary Malignancy-Lung |
B22.00 | Malignant neoplasm of trachea, bronchus and lung | Primary Malignancy-Lung |
B22y.00 | Malignant neoplasm of other sites of bronchus or lung | Primary Malignancy-Lung |
B22z.00 | Malignant neoplasm of bronchus or lung NOS | Primary Malignancy-Lung |
B22z.11 | Lung cancer | Primary Malignancy-Lung |
BB5S200 | [M]Bronchiolo-alveolar adenocarcinoma | Primary Malignancy-Lung |
BB5S211 | [M]Alveolar cell carcinoma | Primary Malignancy-Lung |
BB5S212 | [M]Bronchiolar carcinoma | Primary Malignancy-Lung |
BB5S400 | [M]Alveolar adenocarcinoma | Primary Malignancy-Lung |
Byu2000 | [X]Malignant neoplasm of bronchus or lung, unspecified | Primary Malignancy-Lung |
ZV10100 | [V]Personal history of malig neop of trachea/bronchus/lung | Primary Malignancy-Lung |
ZV10111 | [V]Personal history of malignant neoplasm of bronchus | Primary Malignancy-Lung |
ZV10112 | [V]Personal history of malignant neoplasm of lung | Primary Malignancy-Lung |
ICD10 code | ICD10 term | Condition |
C33 | Malignant neoplasm of trachea | Primary Malignancy-Lung |
C34 | Malignant neoplasm of bronchus and lung | Primary Malignancy-Lung |
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Lung Cancer Screening Trial | Recruitment Period | Number of Subjects Approached | Number of Subjects That Responded | Approach Response Rate | Number of Eligible Subjects That Consented | % of Respondents Randomised | Method of Recruitment |
---|---|---|---|---|---|---|---|
NELSON [6] | 2003–2006 | 606,409 | 150,920 | 24.9% | 15,822 | 10.5% | Direct mail |
ITALUNG [22] | 2004–2006 | 71,232 | 17,055 | 23.9% | 3206 | 18.8% | Direct mail |
LUSI [23] | 2007–2011 | 292,440 | 95,797 | 32.8% | 4052 | 4.2% | Direct mail and mass media |
NLST [18] | 2002–2004 | n/a | 53,454 | n/a | 52,486 | n/a | Direct mail, mass media and outreach |
UKLS [8] | 2011–2014 | 247,354 | 98,746 | 39.9% | 4061 | 4.1% | Direct mail |
LSUT [24] | 2015–2017 | 2012 | 1058 | 52.6% | 770 | 72.8% | Direct mail |
LHC Manchester [25] | 2016–2018 | 16,402 | 2827 | 17.2% | 1384 | 49.0% | Searched GP records to send direct mail invitations |
LHC Liverpool [26] | 2016–2018 | 11,526 | 4566 | 39.6% | 1318 | 28.9% | Searched GP records to send direct mail invitations |
ECLS [9] | 2013–2016 | 77,077 | 18,657 | 24.2% | 12,209 | 65.4% | Searched GP records to send direct mail invitations, mass media and outreach |
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Brown, L.; Agrawal, U.; Sullivan, F. Using Electronic Medical Records to Identify Potentially Eligible Study Subjects for Lung Cancer Screening with Biomarkers. Cancers 2021, 13, 5449. https://doi.org/10.3390/cancers13215449
Brown L, Agrawal U, Sullivan F. Using Electronic Medical Records to Identify Potentially Eligible Study Subjects for Lung Cancer Screening with Biomarkers. Cancers. 2021; 13(21):5449. https://doi.org/10.3390/cancers13215449
Chicago/Turabian StyleBrown, Lamorna, Utkarsh Agrawal, and Frank Sullivan. 2021. "Using Electronic Medical Records to Identify Potentially Eligible Study Subjects for Lung Cancer Screening with Biomarkers" Cancers 13, no. 21: 5449. https://doi.org/10.3390/cancers13215449