Synergistic Effect of Ultrasound and Polyethylene Glycol on the Mechanism of the Controlled Drug Release from Polylactide Matrices
Abstract
:1. Introduction
2. Experimental
2.1. Materials and Equipment
2.2. Sample Preparation
2.3. Measurements
2.3.1. In-Vitro Release Study
2.3.2. Weight Loss
2.3.3. Scanning Electron Microscopy (SEM)
3. Results and Discussion
3.1. Effect of Ultrasound on the In-Vitro Release Behavior of MB from PLA
3.2. Effect of PEG on the In-Vitro Release Behavior of MB from PLA, All without Any Ultrasound Treatment
3.3. Effect of Ultrasound and PEG on the In-Vitro Release Behavior of MB from PLA
3.4. Mechanism and Kinetics of the Release of MB from PLA Based Matrices
4. Conclusions
Author Contributions
Acknowledgments
Conflicts of Interest
References
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Sample Name | Content of PLA, % | Content of PEG, % | Content of MB, % |
---|---|---|---|
PLA | 100 | 0 | 1 |
PLA-20%PEG6000 | 80 | 20 | 1 |
PLA-35%PEG6000 | 65 | 35 | 1 |
PLA-50%PEG6000 | 50 | 50 | 1 |
Sample Name | Ultrasound Power, W | Preheating Time, min | Ultrasound Time, min | After-Heating Time, min |
---|---|---|---|---|
PLA/MB H10 | 0 | 5 | 0 | 5 |
PLA/MB U3min-50W | 50 | 5 | 3 | 2 |
PLA/MB U3min-150W | 150 | 5 | 3 | 2 |
PLA/MB U3min-250W | 250 | 5 | 3 | 2 |
PLA/PEG/MB H10 | 0 | 5 | 0 | 5 |
PLA/PEG/MB U3min-50W | 50 | 5 | 3 | 2 |
PLA/PEG/MB U3min-150W | 150 | 5 | 3 | 2 |
PLA/PEG/MB U3min-250W | 250 | 5 | 3 | 2 |
Specimen | Weight of Sample (before Immersion), mg | Weight of Sample (after Immersion), mg | Weight Loss, % |
---|---|---|---|
PLA/MB H10 | 37.07 ± 0.39 | 36.92 ± 0.33 | 0.43 ± 0.18 |
PLA/MB U 3min-50W | 38.19 ± 0.35 | 37.94 ± 0.42 | 0.65 ± 0.19 |
PLA/MB U 3min-150W | 37.39 ± 1.35 | 37.28 ± 1.32 | 0.29 ± 0.10 |
PLA/MB U 3min-250W | 38.07 ± 0.72 | 37.60 ± 0.82 | 1.21 ± 0.24 |
Sample Name | Weight of Tablet (before Immersion), mg | Weight of Tablet (after Immersion), mg | Weight Loss, % |
---|---|---|---|
PLA | 36.42 ± 0.36 | 36.29 ± 0.42 | 0.36 ± 0.18 |
PLA-20%PEG6000 | 39.17 ± 0.71 | 31.80 ± 0.68 | 18.82 ± 0.15 |
PLA-35%PEG6000 | 37.87 ± 1.27 | 27.10 ± 1.01 | 28.47 ± 0.75 |
PLA-50%PEG6000 | 37.07 ± 0.24 | 21.80 ± 0.38 | 40.95 ± 0.08 |
Sample Name | Weight of Sample (before Immersion), mg | Weight of Sample (after Immersion), mg | Weight Loss, % |
---|---|---|---|
PLA/PEG/MB H10 | 35.97 ± 0.63 | 25.52 ± 1.15 | 29.05 ± 4.66 |
PLA/PEG/MB U3min-50W | 35.98 ± 1.32 | 25.45 ± 0.86 | 29.27 ± 1.44 |
PLA/PEG/MB U3min-150W | 34.88 ± 0.89 | 25.09 ± 0.99 | 28.58 ± 2.34 |
PLA/PEG/MB U3min-250W | 35.56 ± 0.79 | 24.7 6± 1.58 | 30.37 ± 2.61 |
Sample | Q | k1, d−1 | k2 × 10−2, d−1/2 | R2 |
---|---|---|---|---|
PLA/PEG/MB H10 | 0.55 | 0.92 | 1.55 | 0.99 |
PLA/PEG/MB U3min-50W | 0.52 | 1.61 | 1.30 | 0.99 |
PLA/PEG/MB U3min-150W | 0.75 | 2.15 | 1.04 | 0.99 |
PLA/PEG/MB U3min-250W | 0.64 | 1.44 | 1.32 | 0.99 |
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Bao, W.; Zhang, X.; Wu, H.; Chen, R.; Guo, S. Synergistic Effect of Ultrasound and Polyethylene Glycol on the Mechanism of the Controlled Drug Release from Polylactide Matrices. Polymers 2019, 11, 880. https://doi.org/10.3390/polym11050880
Bao W, Zhang X, Wu H, Chen R, Guo S. Synergistic Effect of Ultrasound and Polyethylene Glycol on the Mechanism of the Controlled Drug Release from Polylactide Matrices. Polymers. 2019; 11(5):880. https://doi.org/10.3390/polym11050880
Chicago/Turabian StyleBao, Wenting, Xianlong Zhang, Hong Wu, Rong Chen, and Shaoyun Guo. 2019. "Synergistic Effect of Ultrasound and Polyethylene Glycol on the Mechanism of the Controlled Drug Release from Polylactide Matrices" Polymers 11, no. 5: 880. https://doi.org/10.3390/polym11050880