MicroRNAs in Tumor Endothelial Cells: Regulation, Function and Therapeutic Applications
, Maximilian A. Becker †, Luisa Müller †, Katharina Reuss †, Frederik Umlauf †, Tianci Tang, Michael D. Menger and Matthias W. LaschkeRound 1
Reviewer 1 Report
The article “MicroRNAs in tumor endothelial cells: Regulation, function and therapeutic applications” is focused on the specific role of miRNA in the endothelial cells of tumor environment. Multiple review article on the role of miRNA in cancer has been published but the issue of role of miRNA on this specific field has not been exploited. Therefore focusing on this specific issue has important advantage.
The need to address this topic is clearly defined in the end of introduction section.
Authors precise the workflow of literature search, making this review of clear scope of research and appear reliable.
The manuscript is clearly, well written.
Figures that are presents along with the text are good-looking and significantly supplement the main text.
Figures that are presented along with the text are significantly supplement the main text.
In my opinion, this article fully covers the topic and should be published.
Minor comments
1. I feel that more information should be provided on general role of miRNA and its biogenesis including the information like the role if RNA polymerase III beside of RNA polymerase II in transcription of miRNA encoding genes and the sense of discriminating between -3p and -5p miRNA.
2. It should be clearly indicated, at each part of the text, table and illustration whether -3p and -5p variant of specific miRNA is described. This has not was not consequently done by the authors.
Author Response
Please see the attachment.
Author Response File: 
Author Response.pdf
Reviewer 2 Report
The manuscript entitled "MicroRNAs in tumor endothelial cells: Regulation, function and therapeutic applications" by Gu et al. is a well organized, well described systematic review on the relevance, both biological and therapeutical, of microRNAs in the tumor vasculature. The review covers aspects related to i) miRNA regulation in tumor endothelial cells, ii) miRNA effect on the biology of the same cells, and iii) the potential use of miRNAs as specific targets in the development of novel anti-angiogenic therapies. All those aspects are described with simplicity and precision at the same time; I have to congratulate with the authors for the work done.
Author Response
We appreciate the positive feedback from the reviewer. There are no comments that require further clarification.
