Essential Roles of PIEZO1 in Mammalian Cardiovascular System: From Development to Diseases
Abstract
:1. Introduction
2. Structure and Mechanogating Mechanism
3. PIEZO1 in Cardiovascular Development
3.1. PIEZO1 in Embryos
3.2. PIEZO1 in Vascular Development
3.3. PIEZO1 in Cardiac Development
3.4. PIEZO1 in Lymphatic Valve and Arteriovenous Valve Development
4. PIEZO1 in Cardiovascular Homeostasis and Diseases
4.1. Vascular Inflammation
4.2. Blood Pressure
4.3. Cardiac Hypertrophy
4.4. Cardiac Fibrosis
4.5. Heart Failure (HF)
5. Potential Chemical Therapies Targeting PIEZO1
5.1. Agonists
5.1.1. Yoda1
5.1.2. Jedi1 and Jedi2
5.2. Competitive Inhibitors
5.2.1. Dooku1
5.2.2. Tubeimoside I (TBMS1) and Salvianolic Acid B (SalB)
5.3. Non-Competitive Inhibitors
5.3.1. GsMTx-4
5.3.2. Ruthenium Red (RR), Amyloid β (Aβ), and Gadolinium (Gd3+)
5.4. Dietary Lipids
5.5. Others
6. Challenges and Prospects
7. Conclusions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
AAA | abdominal aortic aneurysm | mPIEZO1 | mouse PIEZO1 |
Aβ | amyloid β | MS | mechanosensitive |
ADAM10 | Ca2+-dependent transmembrane abscission enzyme | MT1-MMP | membrane-type-1 matrix metalloproteinases |
AF | atrial fibrillation | Møs | macrophages |
AngII | angiotensin II | NFAT5 | nuclear factor of activated T-cells 5 |
APD | action potential time duration | NF-κB | nuclear factor-κ-gene binding |
ARB | angiotensin II receptor blocker | NPJc | nodose-petrosal-jugular ganglion complex |
AS | atherosclerosis | OH | outer helix |
CaM | calmodulin | OX-LDL | oxidized low-density lipoprotein |
CaN | calcineurin | PAD | peripheral artery disease |
CaMKII | calcium/calmodulin-dependent protein kinase II | PDGF | platelet-derived growth factor |
CAVD | calcified aortic valvular disease | PH | pulmonary hypertension |
CED | C-terminal extracellular domain | PIEZO1fl/fl | floxed PIEZO1 |
CMs | cardiomyocytes | Pitx2 | paired like homeodomain 2 |
COMP | cartilage oligomeric matrix protein | PKA | protein kinase A |
CTD | C-terminal domain | PRP | platelet-rich plasma |
DLL-4 | delta like-4 | RBPJ | recombination signal binding protein for immunoglobulin kappa J region |
E | embryonic day | ROS | reactive oxygen species |
ECM | extracellular matrix | RR | ruthenium red |
ECs | endothelial cells | RyR2 | ryanodine receptor 2 |
EL | extracellular loops | SalB | salvianolic acid B |
ETS1 | ETS proto-oncogene 1 | SERCA2 | sarcoplasmic endoplasmic reticulum calcium ATPase 2 |
FAK | focal adhesion kinase | SMPD3 | sphingomyelin phosphodiesterase 3 |
FBs | fibroblasts | SNPs | single nucleotide polymorphisms |
Gd3+ | gadolinium | SPT | single particle tracking |
HAFBs | human atrial fibroblasts | ST2 | suppression of tumorigenicity 2 |
HCFBs | human cardiac fibroblasts | TAZ | transcription coactivator with PDZ-binding motif |
HDAC4 | histone deacetylase 4 | TBMS1 | tubeimoside I |
HF | heart failure | TGF-β | transforming growth factor-β |
HLI | hindlimb ischemia | THBD | thrombomodulin |
hPIEZO1 | human PIEZO1 | TM | transmembrane |
hUC-MSCs | human umbilical cord mesenchymal stem cells | TMEM150C | transmembrane protein 150C |
ICAM-1 | intercellular cell adhesion molecule-1 | TNC | tenascin C |
IH | inner helices | TNF-α | tumor necrosis factor-α |
IL | interleukin | TRPM4 | transient receptor potential melastatin 4 |
ITG | integrin | TRPV1 | transient receptor potential vanilloid subtype |
JAG-1/2 | jagged1/2 | VCAM-1 | vascular cell adhesion molecule-1 |
JNK | c-Jun N-terminal kinase | VE-cadherin | vascular endothelial cadherin |
KLF | kruppel-like factor | VEGF | vascular endothelial growth factor |
MCFBs | mouse cardiac fibroblasts | VEGFR2 | vascular endothelial growth factor receptor 2 |
MEF2 | myocyte enhancer factor 2 | VECs | vascular endothelial cells |
MI | myocardial infarction | VSMCs | vascular smooth muscle cells |
Mito | mitochondrion | NO | nitric oxide |
MLC2v | myosin light chain 2v | YAP | yes-associated protein |
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Jin, C.; Su, S.; Yu, S.; Zhang, Y.; Chen, K.; Xiang, M.; Ma, H. Essential Roles of PIEZO1 in Mammalian Cardiovascular System: From Development to Diseases. Cells 2024, 13, 1422. https://doi.org/10.3390/cells13171422
Jin C, Su S, Yu S, Zhang Y, Chen K, Xiang M, Ma H. Essential Roles of PIEZO1 in Mammalian Cardiovascular System: From Development to Diseases. Cells. 2024; 13(17):1422. https://doi.org/10.3390/cells13171422
Chicago/Turabian StyleJin, Chengjiang, Sheng’an Su, Shuo Yu, Yue Zhang, Kaijie Chen, Meixiang Xiang, and Hong Ma. 2024. "Essential Roles of PIEZO1 in Mammalian Cardiovascular System: From Development to Diseases" Cells 13, no. 17: 1422. https://doi.org/10.3390/cells13171422