Mitochondrial Involvement in the Adaptive Response to Chronic Exposure to Environmental Pollutants and High-Fat Feeding in a Rat Liver and Testis
Abstract
:1. Introduction
2. Mitochondria and Oxidative Stress Generation in Biological Systems
3. Physiological Adaption to HFD and DDE in the Liver
3.1. HFD Induces Hepatic Fat Accumulation and Cellular Stress Targeting Mitochondria
3.2. DDE Exposure: Hepatic Mechanisms Used to Counteract Liver Damage
3.3. Dietary Fats and DDE Showed No Synergic Effect in Hepatic Stress Generation and Damage
4. Physiological Adaption to HFD and DDE in the Testis
4.1. HFD Alters Testicular Function and Affects Hormonal Homeostasis
4.2. DDE Negatively Affects Spermatogenesis and Testicular Function
4.3. Simultaneous Exposure to HFD + DDE did not Show a Synergic Effect on Testicular Function
5. Conclusions
Funding
Conflicts of Interest
References
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Migliaccio, V.; Di Gregorio, I.; Putti, R.; Lionetti, L. Mitochondrial Involvement in the Adaptive Response to Chronic Exposure to Environmental Pollutants and High-Fat Feeding in a Rat Liver and Testis. Cells 2019, 8, 834. https://doi.org/10.3390/cells8080834
Migliaccio V, Di Gregorio I, Putti R, Lionetti L. Mitochondrial Involvement in the Adaptive Response to Chronic Exposure to Environmental Pollutants and High-Fat Feeding in a Rat Liver and Testis. Cells. 2019; 8(8):834. https://doi.org/10.3390/cells8080834
Chicago/Turabian StyleMigliaccio, Vincenzo, Ilaria Di Gregorio, Rosalba Putti, and Lillà Lionetti. 2019. "Mitochondrial Involvement in the Adaptive Response to Chronic Exposure to Environmental Pollutants and High-Fat Feeding in a Rat Liver and Testis" Cells 8, no. 8: 834. https://doi.org/10.3390/cells8080834