Measuring IGF-1 and IGFBP-3 Profiles in Women Seeking Assisted Reproduction; Relationship to Clinical Parameters (Study 1)
Round 1
Reviewer 1 Report
well written, well designed
The paper is original, they raise a legitimist question about the IGF1, and IGFBP, and ratio and its predictive value for fertility, in different age group of woman
I think is clearly written, has additive information, compare to previous studies related to this topic.
And they address the question, and the conclusions reflect the result of the study.
Author Response
Thank you for your kind Review of our manuscript.
It appears you are quite satisfied with its scientific content.
No specific responses required.
Reviewer 2 Report
Interesting observational study without clinical impact at present. Further research is needed.
References need improvement. Important ones are missing while half of them are publications of the correspondence author.
This is an observational study measuring IGF-1 and IGFBP-3 profiles in women seeking assisted reproduction.
The topic is original. Although studies have assessed the GH supplementation in ART cycles, there is no specific data available on defining the group of patients who might benefit.
The paper is well written and clear to read. The results do collerate with current research. AGHD seems to be related with the well-known feature of age-related poor prognosis in assisted reproduction.
The main question is not conclusively answered and further research is needed. However this is an interesting approach.
Author Response
The Reviewer is satisfied with the general presentation of the study, but notes :
- The study lacks clinical impact, further research required.
- The question of GH supplementation; who will benefit.
- The question about insufficient (external) referencing and domination of internal (corresponding author) referencing.
Please see the attachment.
Author Response File: 
Author Response.pdf
