Characterization of a Zn-Ca5(PO4)3(OH) Composite with a High Content of the Hydroxyapatite Particles Prepared by the Spark Plasma Sintering Process
Abstract
:1. Introduction
2. Materials and Methods
3. Results and Discussion
3.1. Microstructure
3.2. Mechanical Properties
3.3. Corrosion Properties
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
- Zheng, Y.F.; Gu, X.N.; Witte, F. Biodegradable metals. Mater. Sci. Eng. R: Rep. 2014, 77, 1–34. [Google Scholar] [CrossRef]
- Moravej, M.; Mantovani, D. Biodegradable Metals for Cardiovascular Stent Application: Interests and New Opportunities. Int. J. Mol. Sci. 2011, 12, 4250. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Sajjadi, S.A.; Ezatpour, H.R.; Torabi Parizi, M. Comparison of microstructure and mechanical properties of A356 aluminum alloy/Al2O3 composites fabricated by stir and compo-casting processes. Mater. Des. 2012, 34, 106–111. [Google Scholar] [CrossRef]
- Conner, R.D.; Dandliker, R.B.; Johnson, W.L. Mechanical properties of tungsten and steel fiber reinforced Zr41.25Ti13.75Cu12.5Ni10Be22.5 metallic glass matrix composites. Acta Mater. 1998, 46, 6089–6102. [Google Scholar] [CrossRef]
- Gleeson, J.P.; Plunkett, N.A.; O’Brien, F.J. Addition of hydroxyapatite improves stiffness, interconnectivity and osteogenic potential of a highly porous collagen-based scaffold for bone tissue regeneration. Eur. Cells Mater. 2010, 20, 218–230. [Google Scholar] [CrossRef]
- Čapek, J.; Pinc, J.; Msallamová, Š.; Jablonská, E.; Veřtát, P.; Kubásek, J.; Vojtěch, D. Thermal plasma spraying as a new approach for preparation of zinc biodegradable scaffolds: A complex material characterization. J. Therm. Spray Technol. 2019, 28, 826–841. [Google Scholar] [CrossRef]
- Ryan, G.; Pandit, A.; Apatsidis, D.P. Fabrication methods of porous metals for use in orthopaedic applications. Biomaterials 2006, 27, 2651–2670. [Google Scholar] [CrossRef]
- Song, G.; Atrens, A.; Dargusch, M. Influence of microstructure on the corrosion of diecast AZ91D. Corros. Sci. 1998, 41, 249–273. [Google Scholar] [CrossRef]
- Čapek, J.; Jablonská, E.; Lipov, J.; Kubatík, T.F.; Vojtěch, D. Preparation and characterization of porous zinc prepared by spark plasma sintering as a material for biodegradable scaffolds. Mater. Chem. Phys. 2018, 203, 249–258. [Google Scholar] [CrossRef]
- Munir, Z.A.; Anselmi-Tamburini, U.; Ohyanagi, M. The effect of electric field and pressure on the synthesis and consolidation of materials: A review of the spark plasma sintering method. J. Mater. Sci. 2006, 41, 763–777. [Google Scholar] [CrossRef]
- Sairam, K.; Sonber, J.K.; Murthy, T.S.R.C.; Subramanian, C.; Fotedar, R.K.; Nanekar, P.; Hubli, R.C. Influence of spark plasma sintering parameters on densification and mechanical properties of boron carbide. Int. J. Refract. Metals Hard Mater. 2014, 42, 185–192. [Google Scholar] [CrossRef]
- Nouri, A.; Hodgson, P.D.; Wen, C.E. Effect of process control agent on the porous structure and mechanical properties of a biomedical Ti–Sn–Nb alloy produced by powder metallurgy. Acta Biomater. 2010, 6, 1630–1639. [Google Scholar] [CrossRef] [PubMed]
- Joschek, S.; Nies, B.; Krotz, R.; Göpferich, A. Chemical and physicochemical characterization of porous hydroxyapatite ceramics made of natural bone. Biomaterials 2000, 21, 1645–1658. [Google Scholar] [CrossRef]
- Matsunaga, K.; Murata, H.; Mizoguchi, T.; Nakahira, A. Mechanism of incorporation of zinc into hydroxyapatite. Acta Biomater. 2010, 6, 2289–2293. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Koempel, J.A.; Patt, B.S.; O’Grady, K.; Wozney, J.; Toriumi, D.M. The effect of recombinant human bone morphogenetic protein-2 on the integration of porous hydroxyapatite implants with bone. J. Biomed. Mater. Res. 1998, 41, 359–363. [Google Scholar] [CrossRef]
- Arifin, A.; Sulong, A.B.; Muhamad, N.; Syarif, J.; Ramli, M.I. Material processing of hydroxyapatite and titanium alloy (HA/Ti) composite as implant materials using powder metallurgy: A review. Mater. Des. 2014, 55, 165–175. [Google Scholar] [CrossRef]
- White, A.A.; Best, S.M.; Kinloch, I.A. Hydroxyapatite–Carbon Nanotube Composites for Biomedical Applications: A Review. Int. J. Appl. Ceram. Tec. 2007, 4, 1–13. [Google Scholar] [CrossRef]
- Sun, L.; Berndt, C.C.; Gross, K.A.; Kucuk, A. Material fundamentals and clinical performance of plasma-sprayed hydroxyapatite coatings: A review. J. Biomed. Mater. Res. 2001, 58, 570–592. [Google Scholar] [CrossRef]
- Dehestani, M.; Adolfsson, E.; Stanciu, L.A. Mechanical properties and corrosion behavior of powder metallurgy iron-hydroxyapatite composites for biodegradable implant applications. Mater. Des. 2016, 109, 556–569. [Google Scholar] [CrossRef]
- Witte, F.; Feyerabend, F.; Maier, P.; Fischer, J.; Störmer, M.; Blawert, C.; et al. Biodegradable magnesium–hydroxyapatite metal matrix composites. Biomaterials 2007, 28, 2163–2174. [Google Scholar] [CrossRef] [Green Version]
- Ratna Sunil, B.; Ganapathy, C.; Sampath Kumar, T.S.; Chakkingal, U. Processing and mechanical behavior of lamellar structured degradable magnesium–hydroxyapatite implants. J. Mech. Behav. Biomed. Mater. 2014, 40, 178–189. [Google Scholar] [CrossRef] [PubMed]
- Ulum, M.F.; Arafat, A.; Noviana, D.; Yusop, A.H.; Nasution, A.K.; Abdul Kadir, M.R.; Hermawan, H. In vitro and in vivo degradation evaluation of novel iron-bioceramic composites for bone implant applications. Mater. Sci. Eng. C. 2014, 36, 336–344. [Google Scholar] [CrossRef] [PubMed]
- Yang, H.; Qu, X.; Lin, W.; Wang, C.; Zhu, D.; Dai, K.; Zheng, Y. In vitro and in vivo studies on zinc-hydroxyapatite composites as novel biodegradable metal matrix composite for orthopedic applications. Acta Biomater. 2018, 71, 200–214. [Google Scholar] [CrossRef] [PubMed]
- Levy, G.K.; Goldman, J.; Aghion, E. The Prospects of Zinc as a Structural Material for Biodegradable Implants-A Review Paper. Metals 2017, 7, 18. [Google Scholar]
- Gong, H.B.; Wang, K.; Strich, R.; Zhou, J.G. In vitro biodegradation behavior, mechanical properties, and cytotoxicity of biodegradable Zn-Mg alloy. J. Biomed. Mater. Res. Part B 2015, 103, 1632–1640. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Pospisilova, I.; Vojtech, D. Zinc Alloys for Biodegradable Medical Implants. In Materials Science Forum; Longauerova, M., Zubko, P., Eds.; Metallography Xv Trans Tech. Publications Ltd: Stafa-Zurich, Switzerland, 2014; pp. 457–460. [Google Scholar]
- Katarivas Levy, G.; Leon, A.; Kafri, A.; Ventura, Y.; Drelich, J.W.; Goldman, J.; Vago, R.; Aghion, E. Evaluation of biodegradable Zn-1%Mg and Zn-1%Mg-0.5%Ca alloys for biomedical applications. J. Mater. Sci. Mater. Med. 2017, 28, 174. [Google Scholar] [CrossRef]
- Gower-Winter, S.D.; Levenson, C.W. Zinc in the central nervous system: From molecules to behavior. Biofactors 2012, 38, 186–193. [Google Scholar] [CrossRef] [Green Version]
- Cerovic, A.; Miletic, I.; Sobajic, S.; Blagojevic, D.; Radusinovic, M.; El-Sohemy, A. Effects of zinc on the mineralization of bone nodules from human osteoblast-like cells. Biol. Trace Elem. Res. 2007, 116, 61–71. [Google Scholar] [CrossRef]
- Yamaguchi, M. Role of zinc in bone formation and bone resorption. J. Trace Elem. Exp. Med. 1998, 11, 119–135. [Google Scholar] [CrossRef]
- Vojtěch, D.; Kubásek, J.; Šerák, J.; Novák, P. Mechanical and corrosion properties of newly developed biodegradable Zn-based alloys for bone fixation. Acta Biomater. 2011, 7, 3515–3522. [Google Scholar] [CrossRef]
- Bowen, P.K.; Drelich, J.; Goldman, J. Zinc Exhibits Ideal Physiological Corrosion Behavior for Bioabsorbable Stents. Adv. Mater. 2013, 25, 2577–2582. [Google Scholar] [CrossRef] [PubMed]
- Vojtěch, D.; Kubásek, J.; Čapek, J.; Pospíšilová, I. Comparative mechanical and corrosion studies on magnesium, zinc and iron alloys as biodegradable metals. Mater. Tehnol. 2015, 49, 877–882. [Google Scholar] [CrossRef]
- Yong, L.; Wei, X.; Chengcheng, Z.; Biao, G.; Hanfeng, G.; Hao, C.; Fu, J.; Feng, L. Enhanced osseointegration and antibacterial action of zinc-loaded titania-nanotube-coated titanium substrates: In vitro and in vivo studies. J. Biomed. Mater. Res. Part A 2014, 102, 3939–3950. [Google Scholar]
- Ann, L.C.; Mahmud, S.; Bakhori, S.K.M.; Sirelkhatim, A.; Mohamad, D.; Hasan, H.; Seeni, A.; Rahman, R.A. Antibacterial responses of zinc oxide structures against Staphylococcus aureus, Pseudomonas aeruginosa and Streptococcus pyogenes. Ceram. Int. 2014, 40, 2993–3001. [Google Scholar] [CrossRef]
- Soon, L.L.; Zuhailawati, H.; Suhaina, I.; Dhindaw, B.K. Prediction of Compressive Strength of Biodegradable Mg–Zn/HA Composite via Response Surface Methodology and Its Biodegradation. Acta Metall. Sin. 2016, 29, 464–474. [Google Scholar] [CrossRef] [Green Version]
- Salleh, E.M.; Zuhailawati, H.; Ramakrishnan, S.; Dhindaw, B.K. Enhanced Mechanical Properties and Corrosion Behavior of Biodegradable Mg-Zn/HA Composite. Metall. Mater. Trans. A. 2017, 48, 2519–2528. [Google Scholar] [CrossRef]
- Yang, F.; Dong, W.J.; He, F.M.; Wang, X.X.; Zhao, S.F.; Yang, G.L. Osteoblast response to porous titanium surfaces coated with zinc-substituted hydroxyapatite. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. 2012, 113, 313–318. [Google Scholar] [CrossRef]
- Candidato, R.T.; Thouzellier, C.; Pawlowski, L. Evaluation of the in-vitro behavior of nanostructured hydroxyapatite and zinc doped hydroxyapatite coatings obtained using solution precursor plasma spraying. J. Biomed. Mater. Res. Part B Appl. Biomater. 2017, 106, 2101–2108. [Google Scholar] [CrossRef]
- Uysal, I.; Severcan, F.; Tezcaner, A.; Evis, Z. Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite. Prog. Nat. Sci. Mater. Int. 2014, 24, 340–349. [Google Scholar] [CrossRef] [Green Version]
- Yuan, Q.; Wu, J.; Qin, C.; Xu, A.; Zhang, Z.; Lin, Y.; Chen, Z.; Lin, S.; Yuan, Z.; Ren, X.; et al. One-pot synthesis and characterization of Zn-doped hydroxyapatite nanocomposites. Mater. Chem. Phys. 2017, 199, 122–130. [Google Scholar] [CrossRef]
- Müller, L.; Müller, F.A. Preparation of SBF with different HCO3- content and its influence on the composition of biomimetic apatites. Acta Biomater. 2006, 2, 181–189. [Google Scholar] [CrossRef] [PubMed]
- Thümmler, F.; Oberacker, R. Porosity and Pore-related properties. In Introduction to Powder Metallurgy; Maney Publishing for IOM3; The Institute of Materials, Minerals and Mining: London, UK, 1993; ISBN 978-0-901716-26-2. [Google Scholar]
- Zhang, L.; He, Z.Y.; Zhang, Y.Q.; Jiang, Y.H.; Zhou, R. Rapidly sintering of interconnected porous Ti-HA biocomposite with high strength and enhanced bioactivity. Mater. Sci. Eng. C 2016, 67, 104–114. [Google Scholar] [CrossRef]
- Silva, V.V.; Domingues, R.Z.; Lameiras, F.S. Microstructural and mechanical study of zirconia-hydroxyapatite (ZH) composite ceramics for biomedical applications. Compos. Sci. Technol. 2001, 61, 301–310. [Google Scholar] [CrossRef]
- Wu, S.; Liu, X.; Yeung, K.W.K.; Liu, C.; Yang, X. Biomimetic porous scaffolds for bone tissue engineering. Mater. Sci. Eng. R. Rep. 2014, 80, 1–36. [Google Scholar] [CrossRef]
- Zhang, X.; Li, X.W.; Li, J.G.; Sun, X.D. Preparation and mechanical property of a novel 3D porous magnesium scaffold for bone tissue engineering. Mater. Sci. Eng. C 2014, 42, 362–367. [Google Scholar] [CrossRef] [PubMed]
- Čapek, J.; Vojtěch, D. Effect of sintering conditions on the microstructural and mechanical characteristics of porous magnesium materials prepared by powder metallurgy. Mater. Sci. Eng. C. 2014, 35, 21–28. [Google Scholar] [CrossRef]
- Del Campo, R.; Savoini, B.; Muñoz, A.; Monge, M.A.; Pareja, R. Processing and mechanical characteristics of magnesium-hydroxyapatite metal matrix biocomposites. J. Mech. Behav. Biomed. Mater. 2017, 69, 135–143. [Google Scholar] [CrossRef] [PubMed]
- Lee, Y.J.; Elzinga, E.J.; Reeder, R.J. Sorption Mechanisms of Zinc on Hydroxyapatite: Systematic Uptake Studies and EXAFS Spectroscopy Analysis. Environ. Sci. Technol. 2005, 39, 4042–4208. [Google Scholar] [CrossRef]
- Wei, X.; Yates, M.Z. Yttrium-Doped Hydroxyapatite Membranes with High Proton Conductivity. Chem. Mater. 2012, 24, 1738–1743. [Google Scholar] [CrossRef]
- Wellinghausen, N. Immunobiology of gestational zinc deficiency. Br. J. Nutr. 2007, 85, S81–S86. [Google Scholar] [CrossRef]
- Kokubo, T.; Takadama, H. How useful is SBF in predicting in vivo bone bioactivity? Biomaterials 2006, 27, 2907–2915. [Google Scholar] [CrossRef] [PubMed]
- Liu, L.; Meng, Y.; Dong, C.; Yan, Y.; Volinsky, A.A.; Wang, L.N. Initial formation of corrosion products on pure zinc in simulated body fluid. J. Mater. Sci. Technol. 2018, 34, 2271–2282. [Google Scholar] [CrossRef]
- Turianicová, E.; Kaňuchová, M.; Zorkovská, A.; Holub, M.; Bujňáková, Z.; Dutková, E.; Baláž, M.; Findoráková, L.; Balintová, M.; Obut, A. CO2 utilization for fast preparation of nanocrystalline hydrozincite. J. CO2 Util. 2016, 16, 328–335. [Google Scholar] [CrossRef]
- Mahmoudian, M.R.; Basirun, W.J.; Alias, Y.; Ebadi, M. Facile fabrication of Zn/Zn5(OH)8Cl2·H2O flower-like nanostructure on the surface of Zn coated with poly (N-methyl pyrrole). Appl. Surf. Sci. 2011, 257, 10539–10544. [Google Scholar] [CrossRef]
- Hu, Q.; Zhang, G.; Qiu, Y.; Guo, X. The crevice corrosion behaviour of stainless steel in sodium chloride solution. Corros. Sci. 2011, 53, 4065–4672. [Google Scholar] [CrossRef]
Ions | Na+ | K+ | Ca2+ | Mg2+ | Cl− | HCO3− | SO42− | HPO42− |
---|---|---|---|---|---|---|---|---|
(mmol/L) | 142 | 5 | 2.5 | 1 | 109 | 27 | 1 | 1 |
Sample | Theoretical Porosity | Porosity Evaluated by Image Analysis | Porosity Evaluated by Mercury Porosimetry | Average Pore Size (µm) | ||
---|---|---|---|---|---|---|
Pure zinc | 2.7% | 1.7% | 5% | 21 | ||
Zinc matrix | 12.6% | 18% | 10.2% | 10.6% | 15.2% | <1 (Zn–Zn) ~19 (Zn–HA) |
HA | 5.4% | - | 4.6% | <1 |
Materials | UFS (MPa) | Hardness (HV) | CYS (MPa) | UCS (MPa) | Reference |
---|---|---|---|---|---|
Cortical bone | 160 | - | - | 88–230 | [45,46] |
Cancellous bone | - | - | 2–12 | 0.2–80 | [47,48] |
PM Zinc | 167 ± 11 | 33 ± 2 (HV5) | 81 ± 5 | - | This study |
PM Magnesium | 9 | 27 (HV 3) | 33 | 45 | [48] |
Zn/1HA * | - | 46 (HV0.1) | 70 | 157 | [23] |
Zn/5HA * | - | 45 (HV0.1) | 42 | 109 | [23] |
Zn/10HA * | - | 45 (HV0.1) | 47 | 72 | [23] |
Zn/16HA | 113 ± 8 | 24 ± 5 (HV5) | 46 ± 3 | 65 ± 4 | This study |
Mg/5HA | - | 64 (HV1) | 205 | 330 | [49] |
Methods | Weight Loss | AAS | Polarization Resistance | ||
---|---|---|---|---|---|
Samples | mm/year | mg/(cm2·day) | mg/(cm2·day) | mm/year | mg/(cm2·day) |
SPS Zinc | 0.26 | 0.45 ± 0.05 | 0.40 ± 0.03 | 0.85 | 1.72 ± 0.18 |
SPS Zn/HA16 composite | 0.41 | 0.54 ± 0.04 | 0.45 ± 0.07 | 1.52 | 2.81 ± 0.35 |
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Pinc, J.; Čapek, J.; Kubásek, J.; Průša, F.; Hybášek, V.; Veřtát, P.; Sedlářová, I.; Vojtěch, D. Characterization of a Zn-Ca5(PO4)3(OH) Composite with a High Content of the Hydroxyapatite Particles Prepared by the Spark Plasma Sintering Process. Metals 2020, 10, 372. https://doi.org/10.3390/met10030372
Pinc J, Čapek J, Kubásek J, Průša F, Hybášek V, Veřtát P, Sedlářová I, Vojtěch D. Characterization of a Zn-Ca5(PO4)3(OH) Composite with a High Content of the Hydroxyapatite Particles Prepared by the Spark Plasma Sintering Process. Metals. 2020; 10(3):372. https://doi.org/10.3390/met10030372
Chicago/Turabian StylePinc, Jan, Jaroslav Čapek, Jiří Kubásek, Filip Průša, Vojtěch Hybášek, Petr Veřtát, Ivona Sedlářová, and Dalibor Vojtěch. 2020. "Characterization of a Zn-Ca5(PO4)3(OH) Composite with a High Content of the Hydroxyapatite Particles Prepared by the Spark Plasma Sintering Process" Metals 10, no. 3: 372. https://doi.org/10.3390/met10030372