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Open AccessArticle
Identifying the Impact of Chlamydia trachomatis Screening and Treatment on Mother-to-Child Transmission, and Respiratory Neonatal Outcomes in Mexico
by
Gabriel Arteaga-Troncoso
Gabriel Arteaga-Troncoso 1,2,
Marcela López-Hurtado
Marcela López-Hurtado 3,
Gabino Yescas-Buendía
Gabino Yescas-Buendía 4,
María J. de Haro-Cruz
María J. de Haro-Cruz 5,
Iván Alejandro Arteaga-Martínez
Iván Alejandro Arteaga-Martínez 6,
Jesús Roberto Villagrana-Zesati
Jesús Roberto Villagrana-Zesati 7 and
Fernando M. Guerra-Infante
Fernando M. Guerra-Infante 3,5,*
1
Department of Cellular Biology and Development, Instituto Nacional de Perinatología, Ciudad de Mexico 11000, Mexico
2
Military School of Health Officers, Universidad del Ejército y Fuerza Aérea, Secretaría de la Defensa Nacional, Ciudad de Mexico 11650, Mexico
3
Department of Infectology and Immunology, Instituto Nacional de Perinatología, Ciudad de Mexico 11000, Mexico
4
Neonatal Intensive Care Unit, Instituto Nacional de Perinatología, Ciudad de Mexico 11000, Mexico
5
Department of Veterinary Microbiology, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de Mexico 11340, Mexico
6
Department of Morphological Sciences and Human Embryology, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de Mexico 11340, Mexico
7
Department of Gynecology and Obstetrics, Instituto Nacional de Perinatología, Ciudad de Mexico 11000, Mexico
*
Author to whom correspondence should be addressed.
Pathogens 2024, 13(10), 843; https://doi.org/10.3390/pathogens13100843 (registering DOI)
Submission received: 11 July 2024
/
Revised: 6 September 2024
/
Accepted: 24 September 2024
/
Published: 28 September 2024
Abstract
Chlamydia trachomatis (C. trachomatis) screening and treatment in pregnancy allows the opportunity to reduce adverse pregnancy and neonatal outcomes worldwide. Although C. trachomatis infection is easily treated and cured with antibiotics, only some countries have routine pregnancy screening and treatment programs. We therefore evaluated whether just one maternal screening for C. trachomatis is enough to prevent adverse pregnancy and negative neonatal outcomes. Among the 4087 first-time gynecological–obstetric consultations granted at the National Institute of Perinatology in 2018, we selected the study population according to a case–cohort design. Antenatal C. trachomatis screening and treatment interventions were performed on 628 pregnant women using COBAS® TaqMan CT. C. trachomatis DNA was also detected in samples from 157 infants of these mothers. In the maternal cohort, incidence of C. trachomatis infection was 10.5%. The vertical transmission rate was 1.5% for the cohort of mothers who tested positive for C. trachomatis and received treatment, and 29.7% for those with a negative test. By evaluating symptomatic neonatal infection, the hazard rate of perinatal pneumonia was 3.6 times higher in C. trachomatis-positive babies than in C. trachomatis-negative babies. Despite the low rate of mother-to-child transmission in women positive for C. trachomatis, possible maternal infection that is not detected in pregnancy significantly increases the risk of neonatal infection with consequent perinatal pneumonia.
Share and Cite
MDPI and ACS Style
Arteaga-Troncoso, G.; López-Hurtado, M.; Yescas-Buendía, G.; Haro-Cruz, M.J.d.; Arteaga-Martínez, I.A.; Villagrana-Zesati, J.R.; Guerra-Infante, F.M.
Identifying the Impact of Chlamydia trachomatis Screening and Treatment on Mother-to-Child Transmission, and Respiratory Neonatal Outcomes in Mexico. Pathogens 2024, 13, 843.
https://doi.org/10.3390/pathogens13100843
AMA Style
Arteaga-Troncoso G, López-Hurtado M, Yescas-Buendía G, Haro-Cruz MJd, Arteaga-Martínez IA, Villagrana-Zesati JR, Guerra-Infante FM.
Identifying the Impact of Chlamydia trachomatis Screening and Treatment on Mother-to-Child Transmission, and Respiratory Neonatal Outcomes in Mexico. Pathogens. 2024; 13(10):843.
https://doi.org/10.3390/pathogens13100843
Chicago/Turabian Style
Arteaga-Troncoso, Gabriel, Marcela López-Hurtado, Gabino Yescas-Buendía, María J. de Haro-Cruz, Iván Alejandro Arteaga-Martínez, Jesús Roberto Villagrana-Zesati, and Fernando M. Guerra-Infante.
2024. "Identifying the Impact of Chlamydia trachomatis Screening and Treatment on Mother-to-Child Transmission, and Respiratory Neonatal Outcomes in Mexico" Pathogens 13, no. 10: 843.
https://doi.org/10.3390/pathogens13100843
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