Role of TRP Channels in Shaping the Gut Microbiome
Abstract
:1. Introduction
2. Results
2.1. Deletion of TRP-A1 and -V1 Channels Individually (KO) or Both -A1/V1 Together (dKO) Distinctly Impacts Gut Microbiome Diversity
2.2. Deletion of TRP-A1 and -V1 Channels Individually or Both -A1/V1 Together Generates Distinct Microbiome Composition in the Mouse Gut
2.3. Mice with TRP-A1 KO, -V1 KO and -A1/V1 dKO Genotypes Present Unique Gut Microbiome Signatures
2.4. Microbiome-Related Metabolic Functions Involved in Biosynthesis and Metabolism of Lipid and Fatty Acids are Distinctly Modulated upon Deletion of Specific TRP Channels
3. Discussion
4. Materials and Methods
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Nagpal, R.; Mishra, S.K.; Deep, G.; Yadav, H. Role of TRP Channels in Shaping the Gut Microbiome. Pathogens 2020, 9, 753. https://doi.org/10.3390/pathogens9090753
Nagpal R, Mishra SK, Deep G, Yadav H. Role of TRP Channels in Shaping the Gut Microbiome. Pathogens. 2020; 9(9):753. https://doi.org/10.3390/pathogens9090753
Chicago/Turabian StyleNagpal, Ravinder, Santosh Kumar Mishra, Gagan Deep, and Hariom Yadav. 2020. "Role of TRP Channels in Shaping the Gut Microbiome" Pathogens 9, no. 9: 753. https://doi.org/10.3390/pathogens9090753