Duplication, Loss, and Evolutionary Features of Specific UDP-Glucuronosyltransferase Genes in Carnivora (Mammalia, Laurasiatheria)
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. UGT Phylogenetic Analysis and UGT Gene Counts
2.2. Synteny Analysis of UGT Genes
3. Results
3.1. UGT Synteny Analysis and Gene Counts
3.1.1. UGT1A Coding Loci and Isoform Number in Mammals
3.1.2. UGT2A/B Coding Loci and Isoforms Number in Mammals
3.2. Phylogenetic Analysis of UGTs
3.2.1. Phylogenetic Analysis and Sequence Comparison of UGT1As in Carnivora
3.2.2. Phylogenetic Analysis of UGT2Bs in Carnivora
3.3. Sequence Comparison of UGT1As and 2Bs in Carnivora
4. Discussion
4.1. Relations between Diet and UGT2Bs Expansion
4.2. UGT1A Evolution and Adaptation to Species-Specific Diets
4.3. UGT Duplication/Loss and Relation to Functional Glucuronidation
4.4. Limitation of This Study
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Kondo, M.; Ikenaka, Y.; Nakayama, S.M.M.; Kawai, Y.K.; Ishizuka, M. Duplication, Loss, and Evolutionary Features of Specific UDP-Glucuronosyltransferase Genes in Carnivora (Mammalia, Laurasiatheria). Animals 2022, 12, 2954. https://doi.org/10.3390/ani12212954
Kondo M, Ikenaka Y, Nakayama SMM, Kawai YK, Ishizuka M. Duplication, Loss, and Evolutionary Features of Specific UDP-Glucuronosyltransferase Genes in Carnivora (Mammalia, Laurasiatheria). Animals. 2022; 12(21):2954. https://doi.org/10.3390/ani12212954
Chicago/Turabian StyleKondo, Mitsuki, Yoshinori Ikenaka, Shouta M. M. Nakayama, Yusuke K. Kawai, and Mayumi Ishizuka. 2022. "Duplication, Loss, and Evolutionary Features of Specific UDP-Glucuronosyltransferase Genes in Carnivora (Mammalia, Laurasiatheria)" Animals 12, no. 21: 2954. https://doi.org/10.3390/ani12212954