Decline in Sensory Integration in Old Age and Its Related Functional Brain Connectivity Correlates Observed during a Virtual Reality Task
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. VR-HMD Arm-Reaching Task
2.3. Behavioral Data Analyses
2.3.1. Mean Gap Angle Calculation
2.3.2. Statistical Analyses
2.4. MRI Acquisition
2.5. MRI Data Analyses
2.5.1. Preprocessing
2.5.2. Denoising
- Regression of white matter timeseries (utilizing 5 CompCor noise components)
- Regression of CSF timeseries (also using 5 CompCor noise components)
- Accounting for motion parameters and their first-order derivatives (12 factors) [34]
- Removal of outlier scans (up to 41 factors) [29]
- Adjustment for session and task effects, including their first-order derivatives (two factors)
- Correction for linear trends (two factors) within each functional run
2.5.3. Regions of Interest (ROIs)
2.5.4. First-Level Analysis
2.5.5. Group-Level Analyses
3. Results
3.1. Behavioral Difference between Older Adults and Young/Middle-Aged Adults
3.2. rsFC of Older Adults Reflecting the Mean Gap Angle
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Inagaki, S.; Matsuura, H.; Sakurai, K.; Minati, L.; Yoshimura, N. Decline in Sensory Integration in Old Age and Its Related Functional Brain Connectivity Correlates Observed during a Virtual Reality Task. Brain Sci. 2024, 14, 840. https://doi.org/10.3390/brainsci14080840
Inagaki S, Matsuura H, Sakurai K, Minati L, Yoshimura N. Decline in Sensory Integration in Old Age and Its Related Functional Brain Connectivity Correlates Observed during a Virtual Reality Task. Brain Sciences. 2024; 14(8):840. https://doi.org/10.3390/brainsci14080840
Chicago/Turabian StyleInagaki, Satoru, Hirokazu Matsuura, Kazuki Sakurai, Ludovico Minati, and Natsue Yoshimura. 2024. "Decline in Sensory Integration in Old Age and Its Related Functional Brain Connectivity Correlates Observed during a Virtual Reality Task" Brain Sciences 14, no. 8: 840. https://doi.org/10.3390/brainsci14080840