Association of Microvasculature Changes with Visual Outcomes in Idiopathic Epiretinal Membrane Surgery: A Clinical Trial
Abstract
:1. Introduction
2. Methods
2.1. Patients and Study Design
2.2. Surgical Technique
2.3. Pre-, Intra-, and Postoperative Data
2.4. Main Outcome Measures
2.5. Statistical Analysis
3. Results
3.1. Preoperative and Intraoperative Data
3.2. OCTA Parameters in iERM Eyes and Comparison with Those of Fellow Eyes
3.3. Correlation between OCT Parameters, Visual Acuity, and Macular Morphology in iERM Eyes
3.4. Predictive Factors for Postoperative Visual Outcomes
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Baseline Data | Values |
---|---|
Number of eyes, n | 47 |
Age, years (median (IQR)) | 71.0 (8.0) |
Sex, n (%) | |
| 18 (38.3) |
| 29 (61.7) |
Axial length, mm (median (IQR)) | 23.7 (1.1) |
Preoperative lens status, n (%) | |
| 36 (76.6) |
| 11 (23.4) |
Preoperative BCVA, logMAR (median (IQR)) | 0.3 (0.2) |
iERM grade, n (%) | |
| 0 |
| 12 (25.5) |
| 23 (49) |
| 12 (25.5) |
Central macular thickness, µm (median (IQR)) | 480.0 (106.0) |
Surgical procedure, n (%) | |
Combined cataract extraction | 36 (75.6) |
OCTA Parameters | Fellow Eyes | iERM Eyes | p-Value * | |||
---|---|---|---|---|---|---|
M0 | M6 | p a | p b | p c | ||
FAZ area, mm2 | 0.3(0.2) | 0.03(0.03) | 0.08(0.05) | <0.001 | <0.001 | <0.001 |
SCP, mm2 | ||||||
Whole VD | 18.0(1.5) | 16.0(2.5) | 18.0(1.0) | <0.001 | <0.001 | 0.004 |
Foveal VD | 8.0(2.0) | 16.0(2.5) | 13.0(3.0) | <0.001 | <0.001 | <0.001 |
Parafoveal VD | 18.0(2.0) | 16.0(3.0) | 18.0(2.0) | <0.001 | <0.001 | 0.043 |
Perifoveal VD | 20.0(2.5) | 16.0(2.5) | 16.0(3.0) | <0.001 | <0.001 | <0.001 |
DCP, mm2 | ||||||
Whole VD | 17.0(6.0) | 13.0(5.0) | 17.0(3.5) | <0.001 | <0.001 | 0.202 |
Foveal VD | 5.0(2.0) | 11.0(3.0) | 7.0(2.5) | <0.001 | <0.001 | <0.001 |
Parafoveal VD | 17.0(6.0) | 14.0(6.0) | 18.0(4.5) | <0.001 | <0.001 | 0.402 |
Perifoveal VD | 18.0(7.0) | 13.0(6.0) | 18.0(5.0) | <0.001 | <0.010 | 0.709 |
Baseline Parameters | Preoperative logMAR BCVA | Postoperative logMAR BCVA | ||
---|---|---|---|---|
r | p-Value | r | p-Value | |
FAZ area, mm2 | −0.499 | <0.001 | −0.059 | 0.689 |
SCP, mm2 | ||||
Whole VD | −0.276 | 0.059 | −0.394 | 0.006 |
DCP, mm2 | ||||
Whole VD | −0.422 | 0.003 | −0.569 | <0.001 |
Baseline Parameters | iERM Stage | CMT | ||
---|---|---|---|---|
r | p-Value | r | p-Value | |
FAZ area, mm2 | −0.267 | 0.069 | −0.143 | 0.336 |
SCP, mm2 | ||||
Whole VD | 0.288 | 0.049 | 0.164 | 0.270 |
DCP, mm2 | ||||
Whole VD | 0.033 | 0.825 | −0.138 | 0.352 |
Bivariate Analysis | Multivariate Analysis | |||
---|---|---|---|---|
Factors | Beta Coefficient (Standard Deviation) | p | Beta Coefficient (Standard Deviation) | p |
Preoperative BCVA | 0.475 (0.052) | <0.001 | 0.457 (0.064) | <0.001 |
iERM stage | 0.088 (0.040) | 0.034 | 0.037 (0.029) | 0.210 |
Age | 0.008 (0.0038) | 0.026 | 0.002 (0.003) | 0.498 |
Axial length | −0.012 (0.019) | 0.528 | ||
CMT | 0.0001 (0.0004) | 0.675 | ||
Vascular parameters | ||||
Whole VD in the SCP | −0.024 (0.012) | 0.042 | 0.008 (0.023) | 0.728 |
Whole VD in the DCP | −0.013 (0.008) | 0.095 | 0.005 (0.008) | 0.550 |
FAZ area | −0.513 (0.393) | 0.199 | 0.137 (0.153) | 0.375 |
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Henry, M.; Ndiaye, N.C.; Angioi-Duprez, K.; Berrod, J.-P.; Conart, J.-B. Association of Microvasculature Changes with Visual Outcomes in Idiopathic Epiretinal Membrane Surgery: A Clinical Trial. J. Clin. Med. 2024, 13, 4748. https://doi.org/10.3390/jcm13164748
Henry M, Ndiaye NC, Angioi-Duprez K, Berrod J-P, Conart J-B. Association of Microvasculature Changes with Visual Outcomes in Idiopathic Epiretinal Membrane Surgery: A Clinical Trial. Journal of Clinical Medicine. 2024; 13(16):4748. https://doi.org/10.3390/jcm13164748
Chicago/Turabian StyleHenry, Marie, Ndeye Coumba Ndiaye, Karine Angioi-Duprez, Jean-Paul Berrod, and Jean-Baptiste Conart. 2024. "Association of Microvasculature Changes with Visual Outcomes in Idiopathic Epiretinal Membrane Surgery: A Clinical Trial" Journal of Clinical Medicine 13, no. 16: 4748. https://doi.org/10.3390/jcm13164748