Tumor Microenvironment-Responsive Magnetotactic Bacteria-Based Multi-Drug Delivery Platform for MRI-Visualized Tumor Photothermal Chemodynamic Therapy
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Materials
2.2. AMB-1 Cultivation and Characterization
2.3. Preparation of APPF Based on Magnetotactic Bacteria
2.4. In Vitro Photothermal Performance Testing
2.5. Measurement of GSH-Dependent Iron Release
2.6. Intracellular Reactive Oxygen Species (ROS) Detection
2.7. In Vitro Photothermal Therapy
2.8. MRI Measurement
2.9. In Vivo Anti-Tumor Experiment
2.10. Statistical Analysis
3. Results
3.1. Preparation and Characterization of APPF
3.2. APPF Demonstrates Good Photothermal Effects and Induces the Fenton Reaction In Vitro
3.3. APPF Demonstrates Good MRI Capability
3.4. Combined Photothermal and Chemodynamic Anti-Tumor Effect of APPF
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Feng, F.; Li, Q.; Sun, X.; Yao, L.; Wang, X. Tumor Microenvironment-Responsive Magnetotactic Bacteria-Based Multi-Drug Delivery Platform for MRI-Visualized Tumor Photothermal Chemodynamic Therapy. Biology 2024, 13, 658. https://doi.org/10.3390/biology13090658
Feng F, Li Q, Sun X, Yao L, Wang X. Tumor Microenvironment-Responsive Magnetotactic Bacteria-Based Multi-Drug Delivery Platform for MRI-Visualized Tumor Photothermal Chemodynamic Therapy. Biology. 2024; 13(9):658. https://doi.org/10.3390/biology13090658
Chicago/Turabian StyleFeng, Feng, Qilong Li, Xuefei Sun, Li Yao, and Xiuyu Wang. 2024. "Tumor Microenvironment-Responsive Magnetotactic Bacteria-Based Multi-Drug Delivery Platform for MRI-Visualized Tumor Photothermal Chemodynamic Therapy" Biology 13, no. 9: 658. https://doi.org/10.3390/biology13090658