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Biomedicines
Volume 11
Issue 5
10.3390/biomedicines11051346
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Article

Antiproliferative Effect of Inorganic and Organic Selenium Compounds in Breast Cell Lines

by
Nayara Souza da Costa
1,2,
Luíza Siqueira Lima
1,2,
Franciele Aparecida Mendes Oliveira
1,
Maria Eduarda Andrade Galiciolli
1,2,
Mariana Inocêncio Manzano
1,2,
Quelen Iane Garlet
3,
Ana Carolina Irioda
1,2,* and
Cláudia Sirlene Oliveira
1,2,*
1
Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba 80250-060, Brazil
2
Faculdades Pequeno Príncipe, Curitiba 80230-020, Brazil
3
Curso de Medicina, Universidade Católica de Pelotas, Pelotas 96010-280, Brazil
*
Authors to whom correspondence should be addressed.
Biomedicines 2023, 11(5), 1346; https://doi.org/10.3390/biomedicines11051346
Submission received: 2 March 2023 / Revised: 19 April 2023 / Accepted: 25 April 2023 / Published: 3 May 2023
(This article belongs to the Special Issue Role of Trace Elements in Chemoprevention and Cancer Therapy 2.0)
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Abstract

Triple-negative breast cancer (TNBC) is an aggressive, fast-growing tumor that is more likely to spread to distant organs. Among women diagnosed with breast cancer, the prevalence of TNBC is 20%, and treatment is currently limited to chemotherapy. Selenium (Se), an essential micronutrient, has been explored as an antiproliferative agent. Therefore, this study aimed to evaluate the effects of exposure to organic (selenomethionine, ebselen, and diphenyl diselenide) and inorganic (sodium selenate and sodium selenite) Se molecules in different breast cell lines. The compounds were tested at 1, 10, 50, and 100 μM for 48 h in the non-tumor breast cell line (MCF-10A) and TNBC derivatives cell lines (BT-549 and MDA-MB-231). The effects of Se on cell viability, apoptotic and necrotic processes, colony formation, and cell migration were analyzed. Exposure to selenomethionine and selenate did not alter the evaluated parameters. However, selenomethionine had the highest selectivity index (SI). The exposure to the highest doses of selenite, ebselen, and diphenyl diselenide resulted in antiproliferative and antimetastatic effects. Selenite had a high SI to the BT cell line; however, the SI of ebselen and diphenyl diselenide was low in both tumoral cell lines. In conclusion, the Se compounds had different effects on the breast cell lines, and additional tests are needed to reveal the antiproliferative effects of Se compounds.
Keywords: selenium; trace element; triple-negative breast cancer; cell line selenium; trace element; triple-negative breast cancer; cell line

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MDPI and ACS Style

da Costa, N.S.; Lima, L.S.; Oliveira, F.A.M.; Galiciolli, M.E.A.; Manzano, M.I.; Garlet, Q.I.; Irioda, A.C.; Oliveira, C.S. Antiproliferative Effect of Inorganic and Organic Selenium Compounds in Breast Cell Lines. Biomedicines 2023, 11, 1346. https://doi.org/10.3390/biomedicines11051346

AMA Style

da Costa NS, Lima LS, Oliveira FAM, Galiciolli MEA, Manzano MI, Garlet QI, Irioda AC, Oliveira CS. Antiproliferative Effect of Inorganic and Organic Selenium Compounds in Breast Cell Lines. Biomedicines. 2023; 11(5):1346. https://doi.org/10.3390/biomedicines11051346

Chicago/Turabian Style

da Costa, Nayara Souza, Luíza Siqueira Lima, Franciele Aparecida Mendes Oliveira, Maria Eduarda Andrade Galiciolli, Mariana Inocêncio Manzano, Quelen Iane Garlet, Ana Carolina Irioda, and Cláudia Sirlene Oliveira. 2023. "Antiproliferative Effect of Inorganic and Organic Selenium Compounds in Breast Cell Lines" Biomedicines 11, no. 5: 1346. https://doi.org/10.3390/biomedicines11051346

APA Style

da Costa, N. S., Lima, L. S., Oliveira, F. A. M., Galiciolli, M. E. A., Manzano, M. I., Garlet, Q. I., Irioda, A. C., & Oliveira, C. S. (2023). Antiproliferative Effect of Inorganic and Organic Selenium Compounds in Breast Cell Lines. Biomedicines, 11(5), 1346. https://doi.org/10.3390/biomedicines11051346

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