Effect of Operational Variables on the Yield of Chemoenzymatic Oxidation of 2,5-Furandicarboxaldehyde to 2,5-Furandicarboxylic Acid in Fed-Batch and Continuous Packed-Bed Millibioreactor
Abstract
:1. Introduction
2. Material and Methods
2.1. Chemicals
2.2. Analytical Method for the Quantification of FDCA
2.3. Chemoenzymatic Synthesis of FDCA in a Batch Bioreactor
2.4. Chemoenzymatic Synthesis of FDCA in Fed-Batch Bioreactor
2.5. Chemoenzymatic Synthesis of FDCA in a Continuous Packed-Bed Millibioreactor
2.6. Operational Stability of the Biocatalyst
3. Results and Discussion
3.1. Chemoenzymatic Synthesis of FDCA in a Batch Reactor
3.2. Chemoenzymatic Synthesis of FDCA in Fed-Batch Bioreactor
3.3. Chemoenzymatic Synthesis of FDCA in a Continuous Packed-Bed (CPBR) Bioreactor
3.4. Operationalss Stability of the Biocatalyst in a Fed-Batch Bioreactor
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Reaction Conditions | Range |
---|---|
Concentration of DFF (mM) | 10–50 mM |
Biocatalyst loading (mg)/Activity (U) | 100–835 mg/20–167 U |
Amount of H2O2 30% (µL) | 120–1021 µL |
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Balboa, C.; Schrebler, R.A.; Lienqueo, M.E.; Guajardo, N. Effect of Operational Variables on the Yield of Chemoenzymatic Oxidation of 2,5-Furandicarboxaldehyde to 2,5-Furandicarboxylic Acid in Fed-Batch and Continuous Packed-Bed Millibioreactor. Processes 2022, 10, 2095. https://doi.org/10.3390/pr10102095
Balboa C, Schrebler RA, Lienqueo ME, Guajardo N. Effect of Operational Variables on the Yield of Chemoenzymatic Oxidation of 2,5-Furandicarboxaldehyde to 2,5-Furandicarboxylic Acid in Fed-Batch and Continuous Packed-Bed Millibioreactor. Processes. 2022; 10(10):2095. https://doi.org/10.3390/pr10102095
Chicago/Turabian StyleBalboa, Cristian, Rodrigo A. Schrebler, María Elena Lienqueo, and Nadia Guajardo. 2022. "Effect of Operational Variables on the Yield of Chemoenzymatic Oxidation of 2,5-Furandicarboxaldehyde to 2,5-Furandicarboxylic Acid in Fed-Batch and Continuous Packed-Bed Millibioreactor" Processes 10, no. 10: 2095. https://doi.org/10.3390/pr10102095