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10.3390/separations9020035
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Review

Determination of Antibiotic Residues in Aquaculture Products by Liquid Chromatography Tandem Mass Spectrometry: Recent Trends and Developments from 2010 to 2020

by
Yueting Xiao
1,2,
Shuyu Liu
1,*,
Yuan Gao
2,3,
Yan Zhang
2,
Qinghe Zhang
2,3 and
Xiuqin Li
2,3,*
1
School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China
2
Food Safety Laboratory, Division of Metrology in Chemistry, National Institute of Metrology, Beijing 100029, China
3
Key Laboratory of Chemical Metrology and Applications on Nutrition and Health for State Market Regulation, Beijing 100029, China
*
Authors to whom correspondence should be addressed.
Separations 2022, 9(2), 35; https://doi.org/10.3390/separations9020035
Submission received: 28 December 2021 / Revised: 17 January 2022 / Accepted: 26 January 2022 / Published: 29 January 2022
(This article belongs to the Special Issue Advances of Accurate Quantification Methods in Food Analysis)
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Abstract

The issue of antibiotic residues in aquaculture products has aroused much concern over the last decade. The residues can remain in food and enter the human body through the food chain, posing great risks to public health. For the safety of foods and products, many countries have issued maximum residue limits and banned lists for antibiotics in aquaculture products. Liquid chromatography tandem mass spectrometry (LC/MS/MS) has been widely used for the determination of trace antibiotic residues due to its high sensitivity, selectivity and throughput. However, considering its matrix effects during quantitative measurements, it has high requirements for sample pre-treatment, instrument parameters and quantitative method. This review summarized the application of LC/MS/MS in the detection of antibiotic residues in aquaculture products in the past decade (from 2010 to 2020), including sample pre-treatment techniques such as hydrolysis, derivatization, extraction and purification, mass spectrometry techniques such as triple quadrupole mass spectrometry and high-resolution mass spectrometry as well as status of matrix certified reference materials (CRMs) and matrix effect.
Keywords: aquaculture products; antibiotic residues; liquid chromatography tandem mass spectrometry (LC/MS/MS); sample pre-treatment; matrix effects aquaculture products; antibiotic residues; liquid chromatography tandem mass spectrometry (LC/MS/MS); sample pre-treatment; matrix effects

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MDPI and ACS Style

Xiao, Y.; Liu, S.; Gao, Y.; Zhang, Y.; Zhang, Q.; Li, X. Determination of Antibiotic Residues in Aquaculture Products by Liquid Chromatography Tandem Mass Spectrometry: Recent Trends and Developments from 2010 to 2020. Separations 2022, 9, 35. https://doi.org/10.3390/separations9020035

AMA Style

Xiao Y, Liu S, Gao Y, Zhang Y, Zhang Q, Li X. Determination of Antibiotic Residues in Aquaculture Products by Liquid Chromatography Tandem Mass Spectrometry: Recent Trends and Developments from 2010 to 2020. Separations. 2022; 9(2):35. https://doi.org/10.3390/separations9020035

Chicago/Turabian Style

Xiao, Yueting, Shuyu Liu, Yuan Gao, Yan Zhang, Qinghe Zhang, and Xiuqin Li. 2022. "Determination of Antibiotic Residues in Aquaculture Products by Liquid Chromatography Tandem Mass Spectrometry: Recent Trends and Developments from 2010 to 2020" Separations 9, no. 2: 35. https://doi.org/10.3390/separations9020035

APA Style

Xiao, Y., Liu, S., Gao, Y., Zhang, Y., Zhang, Q., & Li, X. (2022). Determination of Antibiotic Residues in Aquaculture Products by Liquid Chromatography Tandem Mass Spectrometry: Recent Trends and Developments from 2010 to 2020. Separations, 9(2), 35. https://doi.org/10.3390/separations9020035

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