Green Innovation and Synthesis of Honeybee Products-Mediated Nanoparticles: Potential Approaches and Wide Applications

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

The authors are suggested to cut down on the 'nanotechnology' part in the first paragraph and merge it with the second. Most of the readers are already familiar with the key attributes of nanotechnology, so there is no need to emphasize nanotechnology over the key attributes of honeybee products, making it an interesting candidate for nanoparticle synthesis.

2) Some of the numbers (with 2 decimal points) shown in the RHS column of Table 1 are confusing. Please replace the first decimal point with a comma.

 3) Some formulas throughout the document need formatting,e.g., the numbers need to be converted to superscripts and subscripts

4) It would be worthwhile to mention existing challenges and future directions in the last paragraph prior to the Conclusions

4) Figure 5: What does the yellow labeling in part A depict?

Comments on the Quality of English Language

There are major mistakes in the spelling, sentence structure and punctuation throughout the document. Some of the sentences do not make any sense because of that, 

Author Response

Response letter_ Reviewer 1: enclosed 

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

The authors present a review manuscript discussing a large variety of nanoparticle compositions and applications. The nanoparticles were prepared by bee corpse extracts, honey, pollen, propolis, bee wax and bee bread. The work is quite comprehensive and interesting, but a vast amount of claims are not referenced, references partially randomly placed, some sentences are not understandable, then there are writing and grammar errors. For this reason, I recommend major revision. To list the error list below was a lot of work, and the list is by all means not exhaustive, there are more errors.

11.      „pol-len“ wrong spelling

22.      „cata-lysts“ wrong spelling

33.      „re-search“ wrong spelling

44.      Page 2 line 55 reference missing

55.      Page 2 line 58 reference missing

66.      Page 2 line 60 reference missing

77.      Page 2 line 61 reference missing

88.      Page 2 line 63 reference missing

99.      Page 2 line 66 reference missing for new types of drug delivery system I suggest PEM capsule reference¹ and their automated production² as proof that they can be upscaled. Btw. These are bottom up synthesis methods.

110.   Page 2 line 69 reference missing

111.   “Page 2 line 63 reference missing” point missing or writing error

112.   Page 3 line 102: 3 references missing for the claim great attention

113.   Page 3 line 107 reference missing.

114.   Page 3 line 117 reference missing.

115.   Page 4 line 149 spelling error “drug'seffectiveness”

116.   Page 4 line 150 reference missing

117.   „nowadays'smedical“

118.   Page 5 line 163 reference missing

119.   Page 5 line 165 reference missing

220.   „,,“ wrong comma setting

221.   „CoFe2O4“ sub-letter error

222.   Continue 3.2. Page 5

223.   Two times “caffeic acid” in one sentence

224.   Page 5 line 194 reference missing

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330.   “ Bee pollen has been used for Ag, Mg, and Au NPs. “ sentence makes no sense, also no reference

331.   Page 6 line 227 reference missing

332.   Page 6 line 228 reference missing

333.   Page 6 line 228 Since when does silver contain carbon, oxygen and nitrogen? The sentence makes no sense, also the authors did not state how the elements get inside and how the particles were in detail synthesized and they should state multi-element particles they contain more than just silver.

334.   Page 6 line 231 for the claim significant efforts 3 references missing

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339.   Why are there two different font sizes in the text?

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449.   Why is there a link blue underlined in the middle of the manuscript? I thought links are properly cited?

550.   Page 7 line 296 reference missing

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557.   Page 8 line 346 writing error

558.   Page 8 line 317 reference missing

559.   Page 11 line 381 reference missing

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661.   Page 11 line 404 reference missing

662.   Page 11 line 405 writing error

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664.   Page 12 line 414 reference missing

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667.   Figure 5 caption font is vastly different from other captions

668.   Page 14 line 465 reference missing

669.   Page 14 line 472 3+ is not superscript

770.   Page 14 line 479 reference missing

771.   Page 15 line 493 comma error

772.   Page 15 line 502 writing error

773.   Table 2 subscript errors

774.   Page 17 line 511 reference missing

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779.   Page 18 line 550 symbol error

880.   Page 18 line 554 font error

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883.   Page 18 line 562 font size error

884.   Page 18 line 564 reference missing

885.   Page 19 line 574 reference missing

886.   Page 19 line 580 reference missing

887.   Page 19 line 583 reference missing

888.   Page 19 line 587 grammar and writing errors

889.   Page 19 line 593 reference missing

990.   Page 19 line 624 different citation style

991.   Page 21 line 635 reference missing

992.   Page 21 line 636 symbol error

993.   Page 21 line 641 reference missing

994.   Page 21 line 660 reference missing

995.   Page 21 line 671 Symbol error

996.   Page 21 line 674 reference missing

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1100.                   Page 22 line 708 reference missing

1101.                   Page 23 line 721+722 different citation style

1102.                   Page 23 line 725 reference missing

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1104.                   Page 23 line 736 reference missing

1105.                   Page 23 line 743 reference missing

1106.                   Page 23 line 744 subscript error

1107.                   Page 23 line 749 reference missing

1108.                   Page 23 line 761 reference missing

1109.                   Page 23 line 762 writing error

1110.                   Page 24 line 763 writing error

1111.                   Page 24 line 771 writing error

1112.                   How can a coating be optimistic?

1113.                   Page 24 line 777 reference missing

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1115.                   Page 24 line 799 reference missing

1116.                   Page 24 line 806 Font error

 

 

References

(1)        Sukhorukov, G. B.; Donath, E.; Lichtenfeld, H.; Knippel, E.; Knippel, M.; Budde, A.; Mohwald, H. Layer-by-Layer Self Assembly of Polyelectrolytes on Colloidal Particles. Colloids Surfaces A Physicochem. Eng. Asp. 1998, 137, 253–266. https://doi.org/10.1016/S0927-7757(98)00213-1.

(2)        Li, W.; Gai, M.; Rutkowski, S.; He, W.; Meng, S.; Gorin, D.; Dai, L.; He, Q.; Frueh, J. An Automated Device for Layer-by-Layer Coating of Dispersed Superparamagnetic Nanoparticle Templates. Colloid J. 2018, 80 (6), 648–659. https://doi.org/10.1134/S1061933X18060078.

 

Comments on the Quality of English Language

many errors, the list is not complete, I was too tired to list all

Author Response

Response letter_ Reviewer 2: enclosed 

Author Response File: Author Response.pdf

Reviewer 3 Report

Comments and Suggestions for Authors

The manuscript submitted for evaluation is a review work and concerns the use of bee honey and its ingredients for the production of metal nanoparticles. In this work, the authors summarized and described the research results to date, but did not conduct a critical analysis of the problem. The problems that need to be solved in the future and the "real" possibilities of using such nanostructures, taking into account the extraordinary value of honey and its ingredients, have not been indicated. In addition, this manuscript requires linguistic correction and correction of typographical errors in words.

Comments on the Quality of English Language

This manuscript requires typological errors.

Author Response

Response letter_ Reviewer 3: enclosed

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

Comments and Suggestions for Authors

The manuscript reads well after the authors incorporated the suggested changes appropriately.

Reviewer 2 Report

Comments and Suggestions for Authors

I did not read everything again, but the manuscript was improved.