Green Innovation and Synthesis of Honeybee Products-Mediated Nanoparticles: Potential Approaches and Wide Applications
Round 1
Reviewer 1 Report
Comments and Suggestions for AuthorsThe authors are suggested to cut down on the 'nanotechnology' part in the first paragraph and merge it with the second. Most of the readers are already familiar with the key attributes of nanotechnology, so there is no need to emphasize nanotechnology over the key attributes of honeybee products, making it an interesting candidate for nanoparticle synthesis.
2) Some of the numbers (with 2 decimal points) shown in the RHS column of Table 1 are confusing. Please replace the first decimal point with a comma.
3) Some formulas throughout the document need formatting,e.g., the numbers need to be converted to superscripts and subscripts
4) It would be worthwhile to mention existing challenges and future directions in the last paragraph prior to the Conclusions
4) Figure 5: What does the yellow labeling in part A depict?
Comments on the Quality of English LanguageThere are major mistakes in the spelling, sentence structure and punctuation throughout the document. Some of the sentences do not make any sense because of that,
Author Response
Response letter_ Reviewer 1: enclosed
Author Response File: Author Response.pdf
Reviewer 2 Report
Comments and Suggestions for AuthorsThe authors present a review manuscript discussing a large variety of nanoparticle compositions and applications. The nanoparticles were prepared by bee corpse extracts, honey, pollen, propolis, bee wax and bee bread. The work is quite comprehensive and interesting, but a vast amount of claims are not referenced, references partially randomly placed, some sentences are not understandable, then there are writing and grammar errors. For this reason, I recommend major revision. To list the error list below was a lot of work, and the list is by all means not exhaustive, there are more errors.
11. „pol-len“ wrong spelling
22. „cata-lysts“ wrong spelling
33. „re-search“ wrong spelling
44. Page 2 line 55 reference missing
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99. Page 2 line 66 reference missing for new types of drug delivery system I suggest PEM capsule reference1 and their automated production2 as proof that they can be upscaled. Btw. These are bottom up synthesis methods.
110. Page 2 line 69 reference missing
111. “Page 2 line 63 reference missing” point missing or writing error
112. Page 3 line 102: 3 references missing for the claim great attention
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115. Page 4 line 149 spelling error “drug'seffectiveness”
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117. „nowadays'smedical“
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220. „,,“ wrong comma setting
221. „CoFe2O4“ sub-letter error
222. Continue 3.2. Page 5
223. Two times “caffeic acid” in one sentence
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330. “ Bee pollen has been used for Ag, Mg, and Au NPs. “ sentence makes no sense, also no reference
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333. Page 6 line 228 Since when does silver contain carbon, oxygen and nitrogen? The sentence makes no sense, also the authors did not state how the elements get inside and how the particles were in detail synthesized and they should state multi-element particles they contain more than just silver.
334. Page 6 line 231 for the claim significant efforts 3 references missing
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339. Why are there two different font sizes in the text?
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449. Why is there a link blue underlined in the middle of the manuscript? I thought links are properly cited?
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667. Figure 5 caption font is vastly different from other captions
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669. Page 14 line 472 3+ is not superscript
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771. Page 15 line 493 comma error
772. Page 15 line 502 writing error
773. Table 2 subscript errors
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779. Page 18 line 550 symbol error
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883. Page 18 line 562 font size error
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888. Page 19 line 587 grammar and writing errors
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990. Page 19 line 624 different citation style
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1101. Page 23 line 721+722 different citation style
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1106. Page 23 line 744 subscript error
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1109. Page 23 line 762 writing error
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1111. Page 24 line 771 writing error
1112. How can a coating be optimistic?
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1116. Page 24 line 806 Font error
References
(1) Sukhorukov, G. B.; Donath, E.; Lichtenfeld, H.; Knippel, E.; Knippel, M.; Budde, A.; Mohwald, H. Layer-by-Layer Self Assembly of Polyelectrolytes on Colloidal Particles. Colloids Surfaces A Physicochem. Eng. Asp. 1998, 137, 253–266. https://doi.org/10.1016/S0927-7757(98)00213-1.
(2) Li, W.; Gai, M.; Rutkowski, S.; He, W.; Meng, S.; Gorin, D.; Dai, L.; He, Q.; Frueh, J. An Automated Device for Layer-by-Layer Coating of Dispersed Superparamagnetic Nanoparticle Templates. Colloid J. 2018, 80 (6), 648–659. https://doi.org/10.1134/S1061933X18060078.
Comments on the Quality of English Language
many errors, the list is not complete, I was too tired to list all
Author Response
Response letter_ Reviewer 2: enclosed
Author Response File: Author Response.pdf
Reviewer 3 Report
Comments and Suggestions for AuthorsThe manuscript submitted for evaluation is a review work and concerns the use of bee honey and its ingredients for the production of metal nanoparticles. In this work, the authors summarized and described the research results to date, but did not conduct a critical analysis of the problem. The problems that need to be solved in the future and the "real" possibilities of using such nanostructures, taking into account the extraordinary value of honey and its ingredients, have not been indicated. In addition, this manuscript requires linguistic correction and correction of typographical errors in words.
Comments on the Quality of English LanguageThis manuscript requires typological errors.
Author Response
Response letter_ Reviewer 3: enclosed
Author Response File: Author Response.pdf
Round 2
Reviewer 1 Report
Comments and Suggestions for AuthorsThe manuscript reads well after the authors incorporated the suggested changes appropriately.
Reviewer 2 Report
Comments and Suggestions for AuthorsI did not read everything again, but the manuscript was improved.