Metrics of Antifungal Effects of Ciprofloxacin on Aspergillus fumigatus Planktonic Growth and Biofilm Metabolism; Effects of Iron and Siderophores
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. CIP Reduces A. fumigatus Biofilm Metabolism in the Absence of Siderophores
3.2. CIP Induces A. fumigatus Planktonic Wildtype Growth, but Reduces Planktonic Growth of a Siderophore-Deficient Mutant
3.3. Iron Induces the Metabolism and Growth of A. fumigatus
3.4. Iron and CIP Interact and Affect A. fumigatus Biofilm Metabolism
3.5. Iron Does Not Further Increase Profungal Effects of CIP on A. fumigatus Planktonic Growth
4. Discussion
5. Impact
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Sass, G.; Scherpe, L.; Martinez, M.; Marsh, J.J.; Stevens, D.A. Metrics of Antifungal Effects of Ciprofloxacin on Aspergillus fumigatus Planktonic Growth and Biofilm Metabolism; Effects of Iron and Siderophores. J. Fungi 2022, 8, 240. https://doi.org/10.3390/jof8030240
Sass G, Scherpe L, Martinez M, Marsh JJ, Stevens DA. Metrics of Antifungal Effects of Ciprofloxacin on Aspergillus fumigatus Planktonic Growth and Biofilm Metabolism; Effects of Iron and Siderophores. Journal of Fungi. 2022; 8(3):240. https://doi.org/10.3390/jof8030240
Chicago/Turabian StyleSass, Gabriele, Lynn Scherpe, Marife Martinez, Julianne J. Marsh, and David A. Stevens. 2022. "Metrics of Antifungal Effects of Ciprofloxacin on Aspergillus fumigatus Planktonic Growth and Biofilm Metabolism; Effects of Iron and Siderophores" Journal of Fungi 8, no. 3: 240. https://doi.org/10.3390/jof8030240