One of the groundbreaking advancements in modern technology is the field of organ-on-a-chip in the realm of bioengineering. This innovative technique, by emulating the structure and functionality of human organs, presents unprecedented opportunities in areas such as drug screening, disease research, and personalized medicine. Organ-on-a-chip is a miniature biologically based microchip that enables biological experiments within a simulated microenvironment of human organs. Through the precise manipulation of cellular interactions, biomaterials, and fluids, organ-on-a-chip can mimic the physiological functions and pathological processes of human organs, providing a more reliable tool for disease research and drug development. In this context, we are pleased to feature some recently published papers centered around the topic of organ-on-a-chip in Bioengineering (ISSN: 2306-5354). These publications encompass various organs and disease domains. These articles showcase the potential of organ-on-a-chip in disease modeling, drug screening, and personalized medicine, while also exploring its value in biological research and medical applications.

1. “A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems”
by Luana A. Osório, Elisabete Silva and Ruth E. Mackay
Bioengineering 2021, 8(8), 113; https://doi.org/10.3390/bioengineering8080113
Available online: https://www.mdpi.com/2306-5354/8/8/113

2. “Versatile Vessel-on-a-Chip Platform for Studying Key Features of Blood Vascular Tumors”
by Marina Llenas, Roberto Paoli, Natalia Feiner-Gracia, Lorenzo Albertazzi, Josep Samitier and David Caballero
Bioengineering 2021, 8(6), 81; https://doi.org/10.3390/bioengineering8060081
Available online: https://www.mdpi.com/2306-5354/8/6/81

3. “Multi-Compartment Lymph-Node-on-a-Chip Enables Measurement of Immune Cell Motility in Response to Drugs”
by Nicholas Hallfors, Aya Shanti, Jiranuwat Sapudom, Jeremy Teo, Georg Petroianu, SungMun Lee, Lourdes Planelles and Cesare Stefanini
Bioengineering 2021, 8(2), 19; https://doi.org/10.3390/bioengineering8020019
Available online: https://www.mdpi.com/2306-5354/8/2/19

4. “Organ-On-A-Chip Database Revealed—Achieving the Human Avatar in Silicon”
by Lincao Jiang, Qiwei Li, Weicheng Liang, Xuan Du, Yi Yang, Zilin Zhang, Lili Xu, Jing Zhang, Jian Li, Zaozao Chen et al.
Bioengineering 2022, 9(11), 685; https://doi.org/10.3390/bioengineering9110685
Available online: https://www.mdpi.com/2306-5354/9/11/685

5. “Organ on Chip Technology to Model Cancer Growth and Metastasis”
by Giorgia Imparato, Francesco Urciuolo and Paolo Antonio Netti
Bioengineering 2022, 9(1), 28; https://doi.org/10.3390/bioengineering9010028
Available online: https://www.mdpi.com/2306-5354/9/1/28

6. “Application of Micro-Engineered Kidney, Liver, and Respiratory System Models to Accelerate Preclinical Drug Testing and Development”
by Hanieh Gholizadeh, Shaokoon Cheng, Agisilaos Kourmatzis, Hanwen Xing, Daniela Traini, Paul M. Young and Hui Xin Ong
Bioengineering 2022, 9(4), 150; https://doi.org/10.3390/bioengineering9040150
Available online: https://www.mdpi.com/2306-5354/9/4/150

7. “A Biomimetic Electrospun Membrane Supports the Differentiation and Maturation of Kidney Epithelium from Human Stem Cells”
by Xingrui Mou, Jessica Shah, Rohan Bhattacharya, Titilola D. Kalejaiye, Bowen Sun, Po-Chun Hsu and Samira Musah
Bioengineering 2022, 9(5), 188; https://doi.org/10.3390/bioengineering9050188
Available online: https://www.mdpi.com/2306-5354/9/5/188

8. “Recent Advances in Drug Delivery System Fabricated by Microfluidics for Disease Therapy”
by Fuhao Jia, Yanbing Gao and Hai Wang
Bioengineering 2022, 9(11), 625; https://doi.org/10.3390/bioengineering9110625
Available online: https://www.mdpi.com/2306-5354/9/11/625

9. “A Bioprinted Heart-on-a-Chip with Human Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Evaluation”
by Alan Faulkner-Jones, Victor Zamora, Maria P. Hortigon-Vinagre, Wenxing Wang, Marcus Ardron, Godfrey L. Smith and Wenmiao Shu
Bioengineering 2022, 9(1), 32; https://doi.org/10.3390/bioengineering9010032
Available online: https://www.mdpi.com/2306-5354/9/1/32

10. “Organs-on-Chips Platforms Are Everywhere: A Zoom on Biomedical Investigation”
by Mohamed Zommiti, Nathalie Connil, Ali Tahrioui, Anne Groboillot, Corinne Barbey, Yoan Konto-Ghiorghi, Olivier Lesouhaitier, Sylvie Chevalier and Marc G. J. Feuilloley
Bioengineering 2022, 9(11), 646; https://doi.org/10.3390/bioengineering9110646
Available online: https://www.mdpi.com/2306-5354/9/11/646