Systemic Lupus Erythematosus: Pathogenesis, Diagnosis and Treatment

The present Special Issue aims to provide a broad updated spectrum of knowledge on pathogenetic, diagnostic, and therapeutic aspects of Systemic Lupus Erythematosus (SLE). Despite significant advances in our understanding of the pathophysiology and optimization of medical care, patients with SLE carry a risk of progressive organ damage accrual, reduced health-related quality of life, and still have significant mortality. The early diagnosis of SLE can be beneficial for long-term outcomes. New tools allow for the earlier classification of SLE, whereas tailored early intervention and treatment strategies targeted at clinical remission or lupus low disease activity state (LLDAS) could offer the opportunity to reduce damage, thus improving long-term outcomes including mortality. Understanding the mechanisms and optimal treatment of comorbidities in SLE, improving the management of hard-to-treat manifestations, and optimizing the use of currently available therapeutics are among the current major unmet needs, and new research on these topics is covered in this Special Issue.