Keywordscyclic permutation; DsbB; homology modeling; phylogeny; sequence conservation; vitamin K; vitamin K 2,3-epoxide; VKOR; VKORC1; VKORC1L1; evolution; subfunctionalization; paralog; vitamin K; VKOR; VKORC1; VKORC1L1; cognition; behavior; diet; older adults; vitamin K; vitamin K epoxide reductase (VKOR); VKORC1; vitamin K; vitamin K 2,3-epoxide; warfarin; VKCFD2; molecular modeling; vitamin K antagonists; menaquinone-7; vitamin K2; cardiovascular calcification; matrix Gla-protein; chronic kidney disease; phylloquinone; prophylaxis; prematurity; deficiency; bleeding; dietary; micronutrients; supplement; nutrition; vitamin K; undercarboxylated prothrombin; deficiency; insufficiency; newborn; bleeding; haemorrhage; prophylaxis; vascular calcification; coronary artery calcification; matrix gla protein; vitamin K2; menaquinone-7; oral anticoagulants; vitamin K; vascular calcification; coumarin; DOACs; vitamin K; epidemiology; vitamin K intake; biomarkers; review; phylloquinone; menaquinone-4; tissue distribution; sex; age; diet; caloric restriction