Reprint

ADP-Ribosylation in Pathogens

Edited by
May 2024
222 pages
  • ISBN978-3-7258-0986-8 (Hardback)
  • ISBN978-3-7258-0985-1 (PDF)

This book is a reprint of the Special Issue ADP-Ribosylation in Pathogens that was published in

Biology & Life Sciences
Medicine & Pharmacology
Public Health & Healthcare
Summary

ADP-ribosylation was discovered over 60 years ago, and much of the research focused on bacterial toxins that employed ADP-ribosylation to kill host cells. However, in the last 20 years, the field has identified many cases where host-mediated ADP-ribosylation can either promote or repress pathogenic infections. It is clear that ADP-ribosylation is a key component of the innate immune response in eukaryotes and bacteria, and many of the mechanistic details of how ADP-ribosylation impacts pathogens have yet to be uncovered. In this Special Issue, we have focused on publishing unique reviews and primary research on the topics of pathogens and ADP-ribosylation. We hope that you will enjoy this collection.

Format
  • Hardback
License and Copyright
© 2024 by the authors; CC BY-NC-ND license
Keywords
coronavirus; alphavirus; SARS-CoV-2; macrodomain; ADP-ribosylation; ADP-ribosylhydrolase; therapeutics; 14-3-3 activated bacterial exotoxins; actin; ADP-ribosylation; Aeromonas salmonicid; protein refolding; type III secretion system; Pseudomonas aeruginosa; ADP-ribosylation; toxin–antitoxin; DarT/DarG; DNA modification; cell growth; phage defence; antimicrobial resistance; ADP-ribosylation; PARylation; MARylation; post-translational modifications; viral infection; antiviral response; IFN-I; innate immunity; ADP-ribosylation; macrodomain; SARS-CoV-2; COVID-19; non-structural protein 3 (NSP3); drug discovery and development; virtual screening; ADP-ribosylation; MARylation; hydrolase; interferon; macrodomain; PARP; RNA-virus; Legionella pneumophila; SidE family; effector; PR-ubiquitination; host-pathogen interaction; ADP-ribosylation; macrodomain; PARP; host–virus evolution; phylogenetics; alphaviruses; coronaviruses; ADP-ribosylation; PARP; PARG; Trypanosoma; Leishmania; poly ADP-ribosylation; Aedes aegypti; tankyrase; PARP; chikungunya virus (CHIKV); immunity; mass spectrometry; proteomics; ADP-ribosylation; poly(ADP-ribose) glycohydrolase; Diphtheria toxin-like ADP-ribosyltransferases; chronic infection; arboviruses; cardiovascular disease; emphysema; alcoholic liver disease; SARS-CoV-2; host–pathogen interactions; coronavirus; SARS-CoV-2; macrodomain; Mac1; ADP-ribosylation; inhibitors; ADP-ribosylhydrolase; PARP1; DNA virus; epigenetic; viral gene regulation

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