Recent Developments in the Synthesis and Functionalization of Nitrogen Heterocycles

doi:10.3390/books978-3-7258-2080-1

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Recent Developments in the Synthesis and Functionalization of Nitrogen Heterocycles

Volume I

Edited by

September 2024

414 pages

ISBN978-3-7258-2079-5 (Hardback)
ISBN978-3-7258-2080-1 (PDF)

https://doi.org/10.3390/books978-3-7258-2080-1 (registering)

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This is a Reprint of the Special Issue Recent Developments in the Synthesis and Functionalization of Nitrogen Heterocycles that was published in

This Reprint is part of the book set Recent Developments in the Synthesis and Functionalization of Nitrogen Heterocycles.

Chemistry & Materials Science

Medicine & Pharmacology

Summary

The purpose of this reprint is to introduce the reader to the latest advances in the chemistry of N-heterocycles, such as the synthesis, reactivity, and applications of aromatic and saturated nitrogen heterocyclic compounds. The role of N-heterocycles in human life is difficult to overestimate; their diverse application spans from the pharmaceutical industry to the production of energetic materials, dyes, and non-linear optical materials, among many other areas. With this reprint, we aim to highlight the most recent and most promising research results in this field, presented in the form of original articles and high-quality reviews.

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Hardback

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Keywords

C–H functionalization; cyclization; indazole products; transition metals catalysis; nitro compounds; Azolo[1,5-a]pyrimidines; CK2 inhibition; antitumor activity; multicomponent reaction; amides; BF₃·Et₂O; debenzylation; nitrogen heterocycles; 2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate; anthranilamide; ethyl levulinate; Amberlyst^® 15; Brønsted acid; cascade reaction; mechanochemistry; quinazolinone; ball mill; azirines; pyrrolines; cycloaddition; annulation; copper catalysis; nitro group; nitropyridines; bis-(het)aryl ethenes; nucleophilic substitution; thiols; UV–Vis spectroscopy; alkoxides; aziridination; manganese; iminoiodinane; nitrogen heterocycles; energetic materials; tetrazine; hydroxytetrazole; oxadiazole; sulfonylureas; DPP-IV inhibitors; diabetes mellitus; peptidomimetics; alkynes; enediynes; heterocycles; benzo[b]thiophene; Bergman cyclization; Nicholas reaction; Sonogashira coupling; benzenesulfonamides; antifolates; folic acids; synthesis; applications; drugs; aziridine; non-activated; nucleophilic; ring-opening; regioselectivity; pyrrole; domino reaction; 1H-indole synthesis; aza–Michael reaction; S_NAr reaction; heteroaromatization; 4-hydroxy-2-pyrone; 4-pyridone; aminoenone; trifluoromethylated heterocycles; regioselective reactions; oxidative cyclization; manganese(IV) oxide; 1,2,4-triazine; phenols; cross-coupling; spiropyrrolidine derivatives; antimicrobial; antioxidant; antidiabetic; ADME; molecular docking and dynamic simulation; sulfur–nitrogen heterocycles; benzo[1,2-d:4,5-d’]bis([1,2,3]thiadiazole); aromatic nucleophilic substitution; Suzuki and Stille cross-coupling reactions; X-ray analysis; estradiol; benzisoxazole; hybrid; cancer selectivity; apoptosis induction; carborane; tetrazole; HEMDs; DFT; single crystal X-ray diffraction; electrochemistry; imidazoles; vinyl azides; click chemistry; mechanochemical synthesis; 1,2,3-triazole; cycloaddition reaction; Rufinamide synthesis; solvent-free; C-glycosyl compound; 1,2,4-triazine; amidrazone; IEDDA; pyridine; aminofurazans; fused furazans; perchlorates; energetic compound; synthesis; X-ray analysis; impact sensitivity; thermal decomposition; combustion; burning rate; 1,2,3-triazoles; nucleobases; Lewis acid; click chemistry; molecular docking; ADME; donor–acceptor cyclopropanes; primary amines; pyrrolidin-2-ones; benz[g]indolizidines; acetylenes; amino acids; C-H activation; annulation; catalysis; isoquinolones; active methylene thioamides; Michael addition; dithiomalondianilide; cyanoacetic esters; [1,2]dithiolo[3,4-b]pyridines; herbicide safeners; cycloaddition; azomethine ylide; pyrrolidine; spiro-compound; imidazole; synthesis; medicinal chemistry; drug discovery; Minisci reaction; heterogeneous photocatalysis; N-hydroxyphthalimide; titanium dioxide; green chemistry; visible light photocatalysis; imidazole; 2-hydroxyphenyl group; hydrogen bond; ESIPT; luminescence; [1,2,4]triazolo[4,3-c]quinazolines; cross-coupling; fluorescence; solvatochromism; pH-sensor; multicomponent domino cyclizations; ethyl trifluoropyruvate; methyl ketones; amino alcohols; γ-lactams; tetrahydropyrrolo[2,1-b]oxazolones; tetrahydropyrrolo[2,1-b]oxazinones; pyrrole; alkaloid; Maillard reaction; crystallization-induced diastereomer transformation; glutamine; hydroxy amino acid; diketopiperazine; heterocycles; thiourea dioxide; TDO; mechanochemistry; heterocycles; pyridine; pyridazine; pyrimidine; pyrazine; organophosphorus compounds; dipyrroloquinoxaline; fluorescence; bathochromic shift; substituent effect; energy gap; N-trifluoromethyl group; heterocycles; imidates; iminonitriles; nitrostyrenes; 2-aminopyridine; N-heterocycles; pyrrole; 1,3,4-oxadiazole; Maillard reaction; D-ribose; L-amino acid; pyrrole-2-carbaldehyde; iodine effect; antibacterial activity; sustainable synthesis; aromatic N-heterocycles; solid acids; nanoparticles; microwaves; ultrasounds; visible light activation; high hydrostatic pressure; electrochemistry; biomass; 1,3-diynamides; ynamides; alkynes; homogeneous catalysis; heterocycles; annulation reactions; cycloaddition cascade reactions; helical twisted frontier molecular orbitals (Hel-FMO); Hexa-dehydro-Diels–Alder (HDDA) reaction; quinolines; indoles; carbazoles; N-heterocyclic-based dyes; photosensitizers; photodynamic therapy