Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery

© 2020 by the authors; CC BY-NC-ND license

MC3R; MC4R; mixed pharmacology; tetrapeptides; melanocortins; Plk1; selectivity; polo-box domain; peptide; triazole; PKA; stapled peptide; PKI; pseudosubstrate; kinase inhibitor; IP20; polycationic -amino acids; small antimicrobial peptides; sepsis; peptidomimetics; VEGF₁₆₅; neuropilin-1; molecular dynamics; structure–activity relationship; OBOC; combinatorial chemistry; opioid; drug screen; molecular rotor dye; high throughput screening; sensor chip; peptide; peptide-drug conjugate; mixed-mode pharmacology; GLP-1; GnRH; LHRH; chemical linker; cancer; diabetes; obesity; drug discovery; melanocortin-4 receptor; obesity; peptide agonist; cardiovascular profile; GαS signaling; receptor desensitization; receptor internalization; peptidomimetics; azapeptides; aza-amino acids; β-hairpin; β-sheet; programmed cell death ligand protein 1; pharmacophore; peptide; small molecule; anticancer peptide; therapeutic peptides; support vector machine; random forest; machine learning; classification; peptides; endosomolytic; amphiphilic; fusogenic; influenza hemagglutinin; RBC lysis; peptide permeability; stapled peptide; macrocyclic peptide; D-amino acid; helix-breaker; adaptogenic; autophagy; β-ginkgotide; cytoprotective; cysteine-rich peptides; disulfide-rich scaffold; hyperdisulfide; hypoxia; LIR motif; ginkgo nuts; α-helix mimetics; bis-benzamide scaffold; protein–protein interaction; prostate cancer; androgen receptor; coactivator PELP1; Ranalexin; peptide therapeutics; antibiotics; configuration; antimicrobial activity; cancer vaccine; synthetic vaccine; adjuvant; Toll-like receptor; Pam₂Cys; N-acetylated Pam₂Cys; bioconjugation; lipidation; prostaglandin F_2α; preterm labor; myometrium contractions; peptidomimetic; structure-activity; opioids; multifunctional ligands; peptide design; free energy calculation; d-amino acid scan; alanine scan