Reprint
Recent Progress in Solid Dispersion Technology
Edited by
September 2019
202 pages
- ISBN978-3-03921-501-0 (Paperback)
- ISBN978-3-03921-502-7 (PDF)
This book is a reprint of the Special Issue Recent Progress in Solid Dispersion Technology that was published in
Biology & Life Sciences
Chemistry & Materials Science
Medicine & Pharmacology
Summary
Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD’s natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics.
Format
- Paperback
License
© 2019 by the authors; CC BY-NC-ND license
Keywords
bicaludamide; poloxamer; evaporation; spray drying; dissolution enhancement; nanoaggregates; self-assembly; solid dispersion; classification; manufacturing methods; bioavailability; anticancer drugs; amorphous; solid dispersion; molecular complex; rebamipide; polymer; interaction; stability; characterization; continuous processing; granulation; process development; polyelectrolytes; amorphous solid dispersions; hot melt extrusion; polyelectrolyte excipient matrix; pharmaceutical glass; crystallization tendency; crystallization; nucleation; milling; accelerated stability test; enrofloxacin; ciprofloxacin; amorphous solid dispersion; amorphous polymeric salt; polymer; ball milling; solubility; dissolution; mesoporous; poorly soluble drugs; solubility enhancement; solid dispersion; amorphisation; spray drying; solid dispersions; miscibility; solubility; thermodynamic modeling; phase diagram; molecular dynamics simulation; thermal analysis; spectroscopic techniques; solid dispersion; tadalafil; Wood’s apparatus; intrinsic dissolution rate; Weibull dissolution model; dissolution rate