Reprint
Natural Products and Drug Discovery
Edited by
April 2020
392 pages
- ISBN978-3-03928-746-8 (Paperback)
- ISBN978-3-03928-747-5 (PDF)
This book is a reprint of the Special Issue Natural Products and Drug Discovery that was published in
Chemistry & Materials Science
Medicine & Pharmacology
Summary
Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terrestrial animals and microorganisms, produce very important drug candidate molecules. Specialized metabolites from these varied natural sources can be used directly as bioactive compounds or drug precursors. In addition, due to their broad chemical diversity, they can act as drug prototypes and/or be used as pharmacological tools for different targets. Some examples of natural metabolites that have been developed into useful medical drug are cardiotonic digoxin from Digitalis sp., antimalarial artemisinin from Artemisia annua, anti-cancer taxol from Taxus sp., or podophyllotoxin from Podophyllum peltatum, which served as a synthetic model for the anti-cancer etoposide. The study of natural products is still attracting great scientific attention and their current importance, as a valuable lead for drug discovery, is undebatable. I cordially invite authors to contribute original articles, as well as survey articles, that give the readers of Molecules **MOLECULES NEEDS TO BE ITALICIZED** updated and new perspectives on natural products in drug discovery, including but not limited to natural sources, identification and separation of bioactive phytochemicals, standardization, new biological targets, pre-clinical and clinical trials, pharmacological effects/side effects, and bioassays.
Format
- Paperback
License
© 2020 by the authors; CC BY-NC-ND license
Keywords
cytotoxicity-guided; phenolic derivatives; Dryopteris fragrans; chemical derivatization; immuno-regulation activity; Imperata cylindrica; HPLC; ESI-MS/MS; growth inhibitory activity; cancer; cardamonin; antinociceptive; TRPV1; glutamate; opioid; siphonous green algae; sulfated coumarins; Dasycladus vermicularis; isolation and quantification; Orobanche s.l.; Orobanchaceae; Lamiales; natural products; secondary metabolites; phenylpropanoid glycosides; phenylethanoid glycosides; bioactivities of natural products; chemosystematics; FSE; T2DM; GLUT4; Ca2+; L6 cell; marine peptides; proliferation; migration; angiogenesis; zebrafish; antioxidant activity; flavonoids; isoflavones; phenolics; proanthocyanidins; Trifolium; Leea indica; HPLC-ESI-microTOF-Q-MS/MS; phenolics; dihydrochalcones; Humulus lupulus; prenylated phenolic compounds; antimicrobial agents; methicillin-resistant Staphylococcus aureus; Leishmania mexicana mexicana; Trypanosoma brucei brucei; Astragalus boeticus L.; spectroscopic analysis; cytotoxic activity; human colon cancer cell lines; acetylated astragalosides; Fabaceae; aging; cancer; cardiovascular disease; dementia; diabetes; inflammation; oxidative stress; Harpagophytum procumbens; devil’s claw; harpagoside; spagyric tincture; antioxidant activity; Cleistocalyx operculatus; 2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethylchalcone (DMC); pPancreatic cancer; PANC-1; ACE inhibitory peptide; antihypertensive; bioactive peptides; hypertension; marine resources; terpenes; terpenoids; antimicrobial resistance; synergy; Phyllanthus orbicularis; C-glycoside; flavonoid; natural products; traditional medicine; Cuba; Phyllanthus chamacristoides; chromatography; mass spectrometry; NMR; circular dichroism; stereochemistry; Fideloside; cytokines; anti-inflammatory activity; metabolomics; multivariate data analysis; molecular network; Bacopa monnieri; LC-MS; diabetic neuropathy; neuropathic pain; glucosinolates; Eruca sativa; glucoerucin; H2S; Kv7 potassium channels; artemisinin; Physcomitrella patens; sesquiterpenoids; malaria; biotechnology; ketamine; psychosis; cerebellum; celastrol; oxidative stress; NADPH oxidases; n/a