**4. Conclusions**

A mesoporous hydroxyapatite nanofibrous matrix to mimic the three-dimensional structure of the natural extracellular matrix was successfully fabricated by an electrospinning process based on a sol-gel precursor. p-HApFs exhibited a high drug-loading efficiency and could retard the burst release of TC, as well as maintain antibacterial activity over a period of 7 days. Hence, it is anticipated that p-HApFs have the potential to be used as drug delivery carriers and as bone graft substitutes.

**Author Contributions:** Data curation, S.-W.T. and F.-Y.H.; Formal analysis, S.-W.T., S.-S.H. and F.-Y.H.; Methodology, S.-S.H., W.-X.Y. and Y.-W.H.; Project administration, F.-Y.H.; Writing—original draft, S.-W.T. and F.-Y.H.

**Funding:** This research was funded by the Ministry of Science and Technology of Taiwan, grant number MOST 102-2221-E-019-003-MY3 and MOST 105-2221-E-019-008.

**Conflicts of Interest:** The authors declare no conflict of interests.
