2.2.1. Production of Nanofiber Meshes

Nanofiber meshes (NFMs) were prepared as described elsewhere [48,49]. Briefly, the NFMs were produced by electrospinning of a polymeric solution of 15% (*w*/*v*) PCL dissolved in an organic solvent mixture of chloroform and dimethylformamide (7:3 ratio). This PCL solution was electrospun by applying a voltage of 12 kV, a needle tip-to-ground collector distance of 20 cm and a flow rate of 1 mL/h. After the complete processing of 1 mL of PCL solution, the NFMs were left to dry for 1 day at RT inside a chemical hood, in order to completely evaporate the solvents. All further tests described were performed in samples of 10-mm squares.

#### 2.2.2. Surface Functionalization of Electrospun NFMs

The surface functionalization of electrospun NFMs was performed as described elsewhere [48,49]. Briefly, the NFMs' surface was activated by 4 min of UV-Ozone irradiation (UV-O-Cleaner®, ProCleaner 220, Bioforce Nanoscience, Salt Lake City, UT, USA). Afterwards, the amine groups (–NH2) were inserted by immersion of the irradiated NFM ina1M hexanediamine (HMD) solution during 1 hour at 37 ◦C.
