**4. Conclusions**

In this study, we fabricated PVDF composite nanofibers as potential membranes for bone tissue regeneration using an electrospinning process. The composite nanofibers obtained had fully interconnected porous structures adequate to promote the cell proliferation and the efficient transport of nutrients and metabolic waste. The content of POSS–EGCG conjugate present affected the piezoelectric, antioxidant, and anti-inflammatory properties of the nanofibers, which finally influenced the in vitro bioactivity of the PVDF composite nanofibers. PE06 facilitated the proliferation and differentiation of the MC3T3-E1 cells more effectively compared to the other nanofibers. Based on these results, our simple method is very useful to prepare PVDF composite nanofibers which may contribute to the development of new scaffolding materials for bone tissue regeneration.

**Supplementary Materials:** The following are available online at http://www.mdpi.com/2079-4991/9/2/184/s1, Figure S1: 1H NMR spectrum of the POSS–EGCG conjugate. Figure S2: EDS Si-mapping images of the PVDF composite nanofibers.

**Author Contributions:** Y.-J.K. designed the experiments, analyzed the data, and wrote the manuscript; H.-G.J. and Y.-S.H. performed the fabrication and characterization of materials; K.-H.J. carried out in vitro experiments. All authors have read and approved the final manuscript.

**Funding:** This work was supported by research grants from Daegu Catholic University in 2017.

**Conflicts of Interest:** The authors declare no conflicts of interest.
