*4.5. Nasal*

Currently, supramolecular peptides are used to fabricate electrospun nanofiber scaffolds. Electrospun supramolecular peptide nanofibers have proven their potential for intranasal vaccine delivery. For example, Si and coworkers developed intranasal administrated influenza vaccine using peptide nanofibers consisting of virus polymerase. This self-assembled nanofiber could elicit both humoral and cell mediated immune responses against the influenza virus. To be specific, nasal administrated nanofiber vaccine particles were initially ingested by antigen presenting cells in lung-draining mediastinal lymph nodes and activated both Th1 Th2 to produce the antibody against the given antigen. Furthermore, a high immune response was elicited without any use of vaccine adjuvant [57].
