**4. Conclusions**

This study investigated the potentiality of electrospun PLLA-SBA2 fibres as potential scaffold material for tissue engineering. The bioactive glass (SBA2) micro-sized powder was effectively incorporated in electrospun polymer filaments and the obtained composite system was characterized in terms of morphology and mechanical properties. The acellular bioactivity and biocompatibility of the PLLA-SBA2 fibres was assessed and HCA deposition after 21 days of immersion in SBF was found to be promoted by the embedded bioactive glass particles at a later stage compared with ion release, suggesting this system as multifunctional scaffold appealing for both bone and soft tissue engineering applications.

**Supplementary Materials:** The following are available online at http://www.mdpi.com/2079-4991/9/2/182/s1, Figure S1: EDS analysis performed on PLLA-SBA2 sample before (top) and after 21 days of immersion in SBF solution (bottom), Figure S2: SEM micrographs of neat PLLA fibers (a), composite PLLA-SBA2 fibers (b), composite fibers after 7 days in DPBS (c) and 21 days in SBF (d).

**Author Contributions:** Conceptualization, E.V., A.R.B., D.P. and L.L.; Formal analysis, F.S., M.M. and L.L.; Investigation, F.S., M.M. and L.L.; Methodology, F.S. and L.L.; Resources, E.V., A.R.B. and D.P.; Supervision, A.R.B., D.P. and L.L.; Writing—original draft, F.S.; Writing—review & editing, M.M., E.V., A.R.B., D.P. and L.L.

**Acknowledgments:** The authors wish to thank G. Baldi (CERICOL Research Centre, Italy) for ball milling and particle size analysis BET facilities.

**Conflicts of Interest:** The authors declare no conflict of interest.
