**4. Conclusions**

We report the fabrication of functional PCL-TiO2 coatings by means of the electrospinning technique and coated on cpTi substrates for bone tissue engineering. A range of electrospun nanocomposite scaffolds were fabricated with a novel and simple material consisting of biodegradable polymer PCL (8 wt %) and TiO2 (2, 5 and 7 wt %). When subjected to SBF, the enrichment of a PCL scaffolds was observed when TiO2 nanoparticles were incorporated into it. The TiO2 nanoparticles serves as a basis of inorganic phosphate to enhance bone cell mineralization, demonstrating the bioactive features of the hybrid scaffolds. The results obtained by hybrid PCL/TiO2 coatings have a cell viability more than the uncoated one and pure PCL suggesting the effect of nanoparticles. On the contrary, uncoated cpTi and PCL/7TiO2 appears to be less biocompatible mainly due to minimum contact between the cells-substrate and toxic effect of higher TiO2 content respectively. The synthesized nanocomposite PCL/TiO2 fibers possess the capacity to replicate surface chemical properties of bone and also acts as an antibacterial surface with greater efficacy and performance under strong UV radiation. In particular, PCL/5TiO2 coatings mimic the excellent biological response with respectable antibacterial activity. Because of the effective antibacterial property, no additional covering of the wound for infection prevention is required. The obtained coatings thus can be successfully used to change the surface of cpTi implants to improve their biological properties and antibacterial performance.

**Author Contributions:** Conceptualization, A.S.K.K.; Data curation, A.S.K.K.; Formal analysis, A.S.K.K.; Investigation, A.S.K.K.; Methodology, A.S.K.K.; Supervision, T.S.S.K., M.D. and S.R.; Validation, A.S.K.K. and R.S.; Writing—original draft, A.S.K.K.; Writing—review & editing, A.S.K.K. and R.S.

**Funding:** This research received no external funding.

**Conflicts of Interest:** The authors declare no conflict of interest.
