Anticancer Agents

Not only antibiotics, but also many other types of drugs, such as anticancer drugs, have been applied to the scaffolds of electrospun mats for chemotherapy. Diverse anticancer drugs, such as doxorubicin (Dox), paclitaxel (PTX), dichloroacetate and platinum complexes have been incorporated into the electrospun fibers for localized postoperative chemotherapy sessions. For instance, Xu et al. fabricated PEG-PLLA-loaded electrospun fibers via an water-in-oil emulsion method in which the aqueous phase was the hydrophilic drug, and the oily phase was the chloroform solution of PEG-PLLA [75]. The drug was well and uniformly dispersed in the PEG-PLLA fibers by using the electrospinning technique. In the same way, they successfully incorporated hydrophobic Paclitaxel (PTX) and DOX, which were simultaneously added to the nanofiber scaffolds via the emulsion electrospinning method; subsequently, multiple drug delivery was studied [76]. In contrast, Xe et al. prepared an electrospun scaffold of (30/70) PLA/PLGA blended fiber with the addition of cisplatin, and the results showed a 90% encapsulation efficiency; the sustained release of drug was noted for 75 days in the in vitro treatment of glioma [77].
