**5. Experimental Models of OC**

The development of effective anti OC siRNA and delivery strategies depends on the employment of adequate models of the disease. Available models include cellular and animal models. Recently, conglomerates of cells cultured in 3D and defined spheroids have been proposed as a useful model. Finally, mathematical modeling is gaining interest as a way to better understand the biological phenomena in siRNA effects and delivery. Herein, we have briefly summarized the features of the available models, highlighting their advantages and disadvantages.
