**3. Aquatic Environment**

Most of the antimicrobials/antibiotics used for various purposes and that from manufacturing plant effluents end up in the aquatic systems of the world environment, as well as the resistant bacteria and resistance genes generated by them. Thus, there are reports of their occurrence in hospital wastewater [14–18], rivers [19–21], rainwater-harvesting tanks [22], canal waters [23], recreational waters [24], municipal/community wastewater [25], and pharmaceutical plant effluent [26]. These wastewater discharges further have impact on various water bodies and contaminate them [27].
