Sulfonamides Derivatives

All the sulfonamides studied belonged to NGC. The three classes and antibiotics studied were Diaminopyrimidine inhibitor (Trimethroprim), Sulfonamides (sulfamethoxazole, sulphadimidine, and triple sulphur), and sulfonamides-diaminopyrimidine inhibitor combination (co-trimoxazole). The reported proportional resistance level in these classes of antibiotics was the most heightened. The combination (co-trimoxazole) was the most studied and 55% of the studies on it reported "high" to "very high resistance level" from organisms studied. The triple sulphur had only one report and the study reported "very high resistance" level to it. Sulphadimidine had eight out of nine reports (90%) to be "very high resistance level", while trimethoprim and sulfamethoxazole both had 55% that reported a "high" to "very high resistance" level (Figure 3e, Table 4, Figure S10).

**Figure 3.** *Cont*.

**Figure 3.** Number of reports of antimicrobial resistance levels of (**a**) β-lactam derivatives, (**b**) Quinolones; (**c**) Aminiglycosides; (**d**) Macrolides, Phenicols, and Tetracyclines; and (**e**) Sulfonamides derivatives antimicrobials.

### Other Classes of Antibiotics

The other classes contributed a minute number of report findings, with each class consisting of one antibiotic only; hence, they were pooled together for analysis. Among them, nitrofuran was the most studied and had a high resistance level like vancomycin and fosfomycin, with 50% of the reports having a "high" to "very high resistance" from the organisms studied. In this group, colistin and mupirocin were the most sensitive because they had all reports on them as the "no resistance" level; rifampicin had all its report as "very low resistance", while teicoplan had the highest resistance, with all the reports on it as "very high resistance" from organisms studied. Then fusidic acid responded to the isolates, with about 70% of the reports to be "very high resistance" (Figures S11 and S12).
