Quinolones

This was the second most studied (21.1%) class of antibiotics (Table 4). It comprised nine antimicrobials, with Ciprofloxacin as the most studied. Lomeofloxacin, of the second generation antibiotics, had the highest resistance level, with over 65% of its reports being "high resistance" to "very high resistance" (Figure 3b, Figure S7). The pattern of resistance had little difference along the generation within this class.

#### Aminoglycosides

These constituted 17.77% of the studied antibiotics (Table 4), with gentamycin and streptomycin dominating the antibiotics researched in this group. Streptomycin had the highest level of resistance from organisms tested, with a proportion of 40% of its report to be "high to very high resistance" (Figure 3c, Tables 3 and 4, Figure S8). Apramycin was the only antibiotic that was not resisted; all reports on it had "no resistance", while spectinomycin had 80% of its reports with no resistance. The antibiotics in this class demonstrated various patterns of resistance levels (Figure 3c, Figure S8).

### Macrolide, Phenicol, and Tetracycline

All these three classes belonged to the NGC. Tetracycline, chloramphenicol, and erythromycin dominated, in descending order, respectively. Tetracycline had the highest level of resistance, with 58% of its report to be "high" to "very high resistance" from the organisms researched. It was followed by erythromycin (50%) and chloramphenicol (40%) had "high" to "very high resistance", then clindamycin, with 60% of reports on it being "high resistance". Tigercycline was the only one that had all the reports on it as "no resistance" and florfenicol, with 65% as no resistance (Figure 3d, Figure S9).
