*4.16. Statistical Analysis*

All data are expressed as the mean ± SD. Comparisons between groups were analyzed using one-Way Analysis of variance (ANOVA) followed by the Bonferroni *t*-test. A *p* value <0.05 was accepted as statistically significant.

**Author Contributions:** M.B. and C.F. conceived and designed the experiments; M.B., V.B., A.M. and G.E. performed the experiments; M.B., C.F., V.B., A.M., G.E., D.P. and N.T. analyzed the results; T.L. enrolled patients; M.B. and C.F. drafted the paper.

**Acknowledgments:** This study was supported by "Fondi di Ateneo" research funding from the University of Florence awarded to Claudia Fiorillo.

**Conflicts of Interest:** The authors declare no conflict of interest.
