**Appendix A**

### *Morphological Analysis of Films and Fibers*

To verify the absence of crystals in the drug-loaded membranes, SEM analysis was performed. In Figure A1, representative images of the top-view and cross-section of ciprofloxacin-loaded foils (88 mmol) are reported.

**Figure A1.** SEM images of the top-view ( **A**) and cross-section (**B**) of a ciprofloxacin-loaded PVP foils.

Figure A2 shows representative SEM images of the ciprofloxacin-loaded nanofibers (2.2, 44, and 88 mmol). The diameter of the fibers was determined using ImageJ software. Approximately 100 measurements were taken to obtain the diameter distribution of each type of fiber mat.

**Figure A2.** (**A**–**C**) Top-view SEM images of the PVP nanofibers loaded with (**A**) 1.2, (**B**) 30, and (**C**) 60 mg of ciprofloxacin respectively.
