5.2.7. Compudose

This is a subdermal implant formulated on the basis of dispersing estradiol crystals in a viscous silicone elastomer and coating the dispersion over a silicone rod by extrusion technique to form a cylindrically-shape implant (Figure 18). Compudose is subcutaneously implanted for a duration of 200 to 400 days for the delivery of estradiol [146,147].

**Figure 18.** Compudose implant.

5.2.8. Polymeric Membrane-Based Drug Delivery Systems as Commercialized Formulations

Polymers form the basis of a significant number of membrane-based drug delivery systems. In fact, advances in the field of polymer sciences have paved the way for a large number of membrane-based drug delivery system designs that have considerable flexibility and functions [148–150]. Table 2 summarizes various formulations of drug delivery systems emphasizing the physico-chemical and mechanical properties of various polymers being used in commercially available membrane drug delivery systems.


**Table 2.** Various formulations of drug delivery systems emphasizing the physico-chemical and mechanical properties of various polymers being used in commercially


**Table 2.** *Cont.*

polyacrylamide

Corning


**Table 2.** *Cont.*
