**4. Conclusions**

In this study, the development of a new wound dressing for possible application in wound healing was demonstrated. The wound dressing comprises an alginate membrane and PCL nanoparticles stabilized with Pluronic® F-68 with curcumin inside. This new system was designed with a mixture of aqueous plasticizers to confer high-strength mechanical properties. The characterization of the formulation exhibited that it possesses a high absorbency capacity for the removal of possible exudates, transparency for monitoring the wound bed, the presence of pores with controlled dimensions that could facilitate the transpiration of the wound as a synthetic skin substitute, and the gradual release of the drug according to the ex vivo and in vivo studies. In addition, the high adherence of the wound dressing should be noted even in dry skin, as well as its degradation at later times. Therefore, all of these advantages reveal our wound dressing as a good option for wound healing without the need for its removal from the patient.

**Author Contributions:** Conceptualization, G.L.-G.; methodology, M.C.G.-A., R.A.M.-F., and M.L.D.P.-A.; validation, I.H.C.-F., C.D.F.-H., and B.F.; formal analysis, M.C.G.-A., R.A.M.-F., M.L.D.P.-A., and G.L.-G.; investigation, M.C.G.-A., R.A.M.-F., and G.L.-G.; resources, M.C.G.-A., R.A.M.-F., M.L.D.P.-A., and G.L.-G.; data curation, M.C.G.-A., R.A.M.-F., M.L.D.P.-A., Z.U.-M., H.C., and G.L.-G.; writing—original draft preparation, M.C.G.-A., R.A.M.-F., M.L.D.P.-A., Z.U.-M., H.C., and G.L.-G.; writing—review and editing, M.C.G.-A., R.A.M.-F., Z.U.-M., D.M.G.-G., J.J.M., M.G.-T., O.D.R.-H., G.F.-G., I.H.C.-F., C.D.F.-H., B.F., H.C., and G.L.-G.; visualization, G.L.-G.; supervision, M.L.D.P.-A., Z.U.-M., H.C., and G.L.-G.; project administration, M.L.D.P.-A. and G.L.-G.; funding acquisition, G.L.-G.

**Funding:** This research was funded by Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México (Becas Posdoctorales, PAPIIT TA 200318) and CONACYT A1-S-15759.

**Conflicts of Interest:** The authors declare no conflict of interest.
