*2.1. Immun'Âge*®*-FPP*® *(Fermented Papaya Preparation)*

The FPP® (Immun'Âge®, patent number 6401792, Osato Research Institute, Gifu, Japan), used in the present study was obtained from *Carica papaya* L. cultivated in Hawaii, followed by yeas<sup>t</sup> fermentation for 10 months and batch-to-batch checking at the Osato Research Institute. FPP® was dissolved in tap water and administrated every day without interruption.
