*2.15. Cell Lysates*

Cells (5 × 10<sup>5</sup> per well) were seeded in six well plates and, after 48 h, treated with 0.05 mg/mL **N-15-M**, **E-11-F**, **Q-14-R** and **A-17-E**. After 24 h, cells were collected, rinsed with 1 mL of PBS 1× and then lysed with modified RIPA buffer in the presence of protease inhibitor cocktail (Complete, Roche®, Basel, Switzerland) [19]. Protein content was estimated with the Lowry method [29].
