**5. Conclusions**

Our results showed the beneficial e ffect of FPP ® on the redox balance and anti-aging e ffect in mice drinking daily FPP ® dissolved in water. Furthermore, our data showed that early treatment induced greater e ffects than late treatment. Lastly, while administered in a non-orthodox way (i.e., dissolved in water, rather than sublingually) the daily FPP ® intake has shown to be highly e ffective in increasing the body anti-oxidant reaction and in improving the molecular signatures of aging.

**Author Contributions:** Conceptualization, M.L. and S.F.; Data curation, M.L., R.D.R., D.M. (Davide Mizzoni), M.A., M.S. and D.M. (Daniele Macchia); Formal analysis, M.L., R.D.R., D.M. (Davide Mizzoni)., M.A., M.S. and D.M. (Daniele Macchia); Funding acquisition, S.F.; Methodology, M.L., R.D.R., D.M. (Davide Mizzoni)., M.A., M.S. and D.M. (Daniele Macchia); Project administration, S.F.; Supervision, M.L. and S.F.; Validation, R.D.R. and D.M. (Davide Mizzoni); Visualization, R.D.R. and D.M. (Davide Mizzoni); Writing—original draft, M.L., R.D.R., D.M. (Davide Mizzoni) and S.F.; Writing—review & editing, M.L., R.D.R. and S.F. All authors have read and agreed to the published version of the manuscript.

**Funding:** This work was supported by OLIMED LIMITED: "The e ffects of fermented papaya fermentation on prevention and control of aggressive melanoma in an immunocompetent mouse model", (National Institute of Health internal classification: Fasc K66).

**Conflicts of Interest:** The authors declare no conflict of interest.
