**4. Conclusions**

This study showed that REO counteracts cognitive performance decrease and anxiety increase resulting from Sco treatment through a mechanism implying mitigation of brain oxidative stress and regulation of AChE activity.

**Author Contributions:** Conceptualization, L.H., L.C., and R.S.B.; Methodology, L.C., R.S.B., G.D., E.T.-C., E.M.N., and G.R.; Formal Analysis, L.C., R.S.B., G.D., and E.T.-C.; Investigation, L.C., R.S.B., G.D., and E.T.-C.; Writing—Original Draft Preparation, L.H., L.C., and R.S.B.; Writing—Review and Editing, L.H.; Supervision, L.H.; and Funding Acquisition, L.H. All authors have read and agreed to the published version of the manuscript.

**Funding:** This project was funded by the Ministry of Research and Innovation within Program 1—Development of the national RD system, Subprogram 1.2—Institutional Performance—RDI excellence funding projects, Contract No. 34PFE/19.10.2018.

**Acknowledgments:** The authors thank Tonia Strano for her skillful technical assistance for GC-MS analysis and Flora Srl for supplying the essential oil subject of this study.

**Conflicts of Interest:** The authors declare no conflict of interest.
