**5. Conclusions**

This study has provided some scientific rationale for these vegetables in the managemen<sup>t</sup> of diseases, as obtained in folklore.

SN leave extracts were able to reduce oxidative stress, and, in particular, they showed the potential in quenching the radical in vitro free cellular system, and restoring the oxidative status among in vitro primary rat astroglial cell cultures exposed to glutamate, which possesses notable antioxidant properties and neuroprotective effects. Furthermore, preventing the increase in glutamate uptake and inhibiting glutamate excitotoxicity, SN1 and SN2 leave polar extracts may represent a new natural therapeutic strategy in the neuro-pathological conditions associated with excitotoxicity.

Therefore, these vegetables may serve as a potential source of natural phenolic antioxidants for functional foods and nutraceuticals for the prevention and managemen<sup>t</sup> of neurodegenerative diseases.

**Author Contributions:** The CRediT taxonomy is listed below to define author contributions to primary research papers and the independent contributions of each author is provided, with the agreemen<sup>t</sup> of all co-authors. Each author on the paper had more CRediT contribution roles, as listed below: conceptualization, A.C., N.A.S.; methodology, A.C., R.A., M.R., N.A.S.; software, G.R.; validation, N.A.S., M.R.; formal analysis, M.R., G.R.; investigation, G.R., R.A.; resources, A.C., R.A., N.A.S., A.D.; data curation, R.A.; G.R., writing—original draft preparation, N.A.S., A.C., R.A.; writing—review and editing, M.R.; visualization, M.R.; supervision, A.C., N.A.S., R.A.; project administration, A.C., R.A., N.A.S.; funding acquisition, M.R.

**Funding:** This research received no external funding.

**Conflicts of Interest:** The authors declare no conflict of interest and the founder added the requested detail. The funder M.R. had roles in methodology, validation, formal analysis, visualization and the decision to publish the results.
