**5. Conclusions**

Intake of HRW for four weeks may not change xenobiotic-metabolizing enzymes and antioxidant activity in liver. Regular consumption of HRW may enhance detoxification process possibly through an increase in the efflux of toxic substances from the liver into bile.

**Author Contributions:** Conceptualization, H.-T.Y.; methodology, H.-T.Y.; software, Y.-H.Y.; validation, H.-T.Y.; formal analysis, Y.-H.Y. and M.-L.L.; investigation, Y.-H.Y. and M.-L.L.; resources, H.-T.Y.; data curation, Y.-H.Y.; writing—original draft preparation, H.-T.Y.; writing—review and editing, H.-T.Y.; visualization, Y.-H.Y.; supervision, H.-T.Y.; project administration, H.-T.Y.; funding acquisition, H.-T.Y. All authors approved the final submitted version.

**Funding:** This research was financially supported by grant-aid (MOST 106-2320-B-039-041-MY3) of the Ministry of Science and Technology, Taiwan.

**Conflicts of Interest:** The authors have no conflicts of interest to report.
