**4. Materials and Methods**

#### *4.1. Chemical and Reagents*

All solvents for the NMR, HR-MS/MS and GC–MS, were obtained from Sigma-Aldrich (Steinheim, Germany) and all LC-MS solvents were ChromaSolv grade, obtained from Fluka Analytical. Ultrapure water (18.2 MΩ) was obtained from a Milli-Q system (Millipore, Bedford, MA, USA).
