**5. Conclusions**

Aging is a progressive biological process that is characterized by an accumulation of various physiological and molecular changes, including an increase in oxidative damage to di fferent biomolecules, leading to cell and tissue dysfunctions. In this study, we evaluated the impact on the epididymis of removing SOD1 using *Sod1*−/− mice. We demonstrated that, using this rodent model, the aging phenotype is exacerbated by increased oxidative damage.

**Author Contributions:** Conceptualization, B.R. A.N. and A.K.; Methodology, A.N. and A.K.; Data Curation, A.N.; Writing—Original Draft Preparation, A.N.; Writing—Review and Editing, B.R. and A.N.; Supervision, Project Administration, and Funding Acquisition, B.R. All authors have read and agreed to the published version of the manuscript.

**Funding:** These studies were funded by a gran<sup>t</sup> from the Canadian Institutes of Health Research (CIHR-TE1-138298).

**Acknowledgments:** We thank the Nicolas Audet, from the Imaging and Molecular Biology Platform of the Department of Pharmacology and Therapeutics in McGill University (Montreal, QC, Canada), for his advice about high-throughput screening and image analysis.

**Conflicts of Interest:** None of the authors has any conflict of interest.
