**5. Conclusions**

The current study demonstrated that LBE had protective effects on renal NLRP3 inflammasome-associated hyperinflammation in T2DM mice. Simultaneously, LBE at a high dose stimulated AMPK/SIRT1 activation and attenuated oxidative stress, although some molecular markers were selectively regulated at different treatment doses of LBE in in T2DM mice. Conclusively, the present study suggests that LB might have potential benefit to prevent and ameliorate hyperglycemia-induced renal inflammation under diabetic conditions.

**Author Contributions:** Conceptualization: Y.L.; data curation: J.E.P.; formal analysis: Y.L. and J.E.P.; investigation: Y.L and S.Y.K.; funding acquisition: Y.L.; methodology: Y.L., J.E.P., and H.L.; supervision: Y.L.; writing, review, and editing: J.E.P., H.L., and Y.L. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research was supported by a gran<sup>t</sup> (2018R1D1A1B07046778) funded by the Ministry of Education, Science and Technology, Republic of Korea.

**Conflicts of Interest:** The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
