*4.3. Oleuropein and NAFLD*

Using C57BL/6J mice fed a high-fat diet (HFD) for eight weeks, an animal model that well mimics human metabolic syndrome, with mice developing steatosis, metabolic and cardiovascular diseases, Porcu et al. [112] found an improvement in liver steatosis in mice fed the HFD with Ole that correlated with an increase of autophagy via the AMPK/ULK1 pathway, compared with animals fed with standard diet.
