**6. Conclusion**

Unexpected properties of several ion channels with importance for the pain field were discussed (Table 1). We hope that the selective and non-comprehensive choices help to transfer knowledge within the field. Considering the possibility that such findings in other channels might explain otherwise not understood issues and facilitate scientific progress.

**Table 1.** Overview for the mentioned noncanonical ion channel features: canonical features not discussed in the review are considered ligand- and voltage-gating, selective permeability, interaction with other proteins, fractional presence at the plasma membrane, heteromerisation, modulation by intracellular cascades, and a change of expression.


**Author Contributions:** C.I.C., C.T., J.M., A.L. (Angelika Lampert), S.B.M., A.L. (Andreas Ludwig), and M.J.M.F. wrote the manuscript.

**Funding:** This research was supported by the Austrian Science Fund (FWF): P 32534.

**Conflicts of Interest:** The authors declare no conflict of interest.
