**8. Summary and Outlook**

Migraine is a common neurological disorder with many intractable cases. Despite the many decades of active investigations of this disorder, the molecular mechanisms implicated in the initial steps of migraine pain remain unclear. The recent studies suggesting Piezo channels as the vascular and neuronal sensors of intracranial mechanical forces present a new view on molecular processes implicated in meningeal nociception leading to migraine headache. These mechanosensitive mechanisms can underlie the worst migraine's symptoms such as mechanical hyperalgesia and pulsating pain. Identification of novel molecular targets in meningeal trigeminovascular nociceptive system such as Piezo channels suggests the new approach to control this devastating neurological condition.

**Funding:** This research was funded by the Finnish Academy, grant number 325392.

**Conflicts of Interest:** The review was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
