**Preface to "Advances in Chemical Analysis Procedures (Part I): Extraction and Instrument Configuration"**

Innovative analytical protocols are needed during all processes involved in chemical analysis, to establish the identities, properties, pureness, bioactivities, quantities, and other main features. Furthermore, modern analytical methods provide accurate information about therapeutic dosage and/or pharmacokinetics about new chemical entities (NCE). During the last few years, new techniques for chemical analysis have been developed that allow separation scientists to ge<sup>t</sup> all the relevant information quickly and accurately even when the analysis is carried out in complex matrices (biological fluids, environmental samples, or food matrices). This Special Issue will highlight and describe the latest innovations in instruments and techniques developed for the extraction, analysis, and characterization of drugs, bioactive compounds, and pollutants in samples that, until recently, were difficult to analyze. Greater attention will be paid to recent developments in sample preparation and extraction techniques, with a focus on modern detection techniques, starting with one of the stalwarts of analytical chemistry laboratories, high-performance liquid chromatography (HPLC), up to more innovative instrumentation such as mass spectrometry, mostly used in biological sciences for detection and quantization of protein.

#### **Marcello Locatelli, Angela Tartaglia, Dora Melucci, Abuzar Kabir, Halil Ibrahim Ulusoy, Victoria Samanidou**

*Special Issue Editors*
