*3.3. Inflammation*

The standard technique for securing nerve grafts in place is to use multiple sutures through the epineurium of the graft and the nerve stumps. However, sutures often cause inflammation and scarring, both of which inhibit axon regeneration [49]. This problem can be overcome by placing a degradable collagen [50] or fibrin [51] conduit around the site of nerve stump anastomosis, which stabilizes the juxtaposition of the nerve stumps. An alternative technique is to apply fibrin glue to the anastomosis site of the nerve stumps [52].
