*4.9. Data Analysis*

The data obtained from at least three independent experiments are expressed as mean ± SD. Wilcoxon rank test was used to evaluate the significant di fference between the two groups. *P* values of less than 0.05 were considered significant di fference.

**Supplementary Materials:** Supplementary materials can be found at http://www.mdpi.com/1422-0067/20/21/ 5505/s1.

**Author Contributions:** Conceptualization, K.S. and S.A.; methodology, H.Y. and A.O.; formal analysis, H.Y. and A.H.; resources, S.A. and H.Y.; data curation, K.S., H.Y. and S.A.; writing—original draft preparation, K.S.; writing—review and editing, S.A.; supervision, A.H.; project administration, K.S.; funding acquisition, S.Y.

**Funding:** This study was supported in part by the Nagasaki University Global Center of Excellence (GCOE) Program, Grant-in-Aid for Scientific Research (22390189) from the Ministry of Education, Culture, Sports, Science and Technology and Research on HIV/AIDS from Health Labor Science Research Grant in Japan.

**Conflicts of Interest:** The authors declare no conflict of interest.
